High-pressure nmr study of water exchange on magnetic resonance imaging contrast agents

Lothar Helm, D. Hugh Powell, Andre E. Merbach, E. Brücher, K. Micskei

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The knowledge of water exchange reaction mechanism in aqueous solutions of Ga3+ polyaminocarboxylates is important for the understanding of the relatively slow water exchange rates measured for these complexes. Variable pressure measurements show a change of mechanism from associatively activated on [Gd(H2O8)]3+- and [Gd(PDTA)(H2O)2]' to probably limiting dissociative on the MRI contrast agents [Gd(DOTA)(H2O)]-, [Gd(DTPA)(H2O)]2-and [Gd(DTPA-BMA)(H2O)].

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalHigh Pressure Research
Volume13
Issue number1-3
DOIs
Publication statusPublished - 1994

Fingerprint

magnetic resonance
pressure measurement
water
aqueous solutions

Keywords

  • activation volumes
  • Gd(III) polyaminocarboxylates
  • high pressure NMR
  • water exchange

ASJC Scopus subject areas

  • Condensed Matter Physics

Cite this

High-pressure nmr study of water exchange on magnetic resonance imaging contrast agents. / Helm, Lothar; Powell, D. Hugh; Merbach, Andre E.; Brücher, E.; Micskei, K.

In: High Pressure Research, Vol. 13, No. 1-3, 1994, p. 109-113.

Research output: Contribution to journalArticle

Helm, Lothar ; Powell, D. Hugh ; Merbach, Andre E. ; Brücher, E. ; Micskei, K. / High-pressure nmr study of water exchange on magnetic resonance imaging contrast agents. In: High Pressure Research. 1994 ; Vol. 13, No. 1-3. pp. 109-113.
@article{dc771856168e412287c7d1a23e638e84,
title = "High-pressure nmr study of water exchange on magnetic resonance imaging contrast agents",
abstract = "The knowledge of water exchange reaction mechanism in aqueous solutions of Ga3+ polyaminocarboxylates is important for the understanding of the relatively slow water exchange rates measured for these complexes. Variable pressure measurements show a change of mechanism from associatively activated on [Gd(H2O8)]3+- and [Gd(PDTA)(H2O)2]' to probably limiting dissociative on the MRI contrast agents [Gd(DOTA)(H2O)]-, [Gd(DTPA)(H2O)]2-and [Gd(DTPA-BMA)(H2O)].",
keywords = "activation volumes, Gd(III) polyaminocarboxylates, high pressure NMR, water exchange",
author = "Lothar Helm and Powell, {D. Hugh} and Merbach, {Andre E.} and E. Br{\"u}cher and K. Micskei",
year = "1994",
doi = "10.1080/08957959408200270",
language = "English",
volume = "13",
pages = "109--113",
journal = "High Pressure Research",
issn = "0895-7959",
publisher = "Taylor and Francis Ltd.",
number = "1-3",

}

TY - JOUR

T1 - High-pressure nmr study of water exchange on magnetic resonance imaging contrast agents

AU - Helm, Lothar

AU - Powell, D. Hugh

AU - Merbach, Andre E.

AU - Brücher, E.

AU - Micskei, K.

PY - 1994

Y1 - 1994

N2 - The knowledge of water exchange reaction mechanism in aqueous solutions of Ga3+ polyaminocarboxylates is important for the understanding of the relatively slow water exchange rates measured for these complexes. Variable pressure measurements show a change of mechanism from associatively activated on [Gd(H2O8)]3+- and [Gd(PDTA)(H2O)2]' to probably limiting dissociative on the MRI contrast agents [Gd(DOTA)(H2O)]-, [Gd(DTPA)(H2O)]2-and [Gd(DTPA-BMA)(H2O)].

AB - The knowledge of water exchange reaction mechanism in aqueous solutions of Ga3+ polyaminocarboxylates is important for the understanding of the relatively slow water exchange rates measured for these complexes. Variable pressure measurements show a change of mechanism from associatively activated on [Gd(H2O8)]3+- and [Gd(PDTA)(H2O)2]' to probably limiting dissociative on the MRI contrast agents [Gd(DOTA)(H2O)]-, [Gd(DTPA)(H2O)]2-and [Gd(DTPA-BMA)(H2O)].

KW - activation volumes

KW - Gd(III) polyaminocarboxylates

KW - high pressure NMR

KW - water exchange

UR - http://www.scopus.com/inward/record.url?scp=0342977059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0342977059&partnerID=8YFLogxK

U2 - 10.1080/08957959408200270

DO - 10.1080/08957959408200270

M3 - Article

AN - SCOPUS:0342977059

VL - 13

SP - 109

EP - 113

JO - High Pressure Research

JF - High Pressure Research

SN - 0895-7959

IS - 1-3

ER -