High-performance liquid chromatography of biologically important, small epimeric peptides and their L, D-amino acid content

I. Ilisz, Z. Pataj, A. Aranyi, A. Péter

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Since most of the proteinogenic α-amino acids contain a chiral carbon atom, the stereoisomers of both these amino acids and the peptides in which they are to be found may possess differences in biological activity in living systems. The important analytical task of the separation of optical isomers is achieved mainly by chromatographic methods. This special review surveys direct and indirect HPLC separations of biologically important, small epimeric peptides and their L,D-amino acid content.

Original languageEnglish
Pages (from-to)287-298
Number of pages12
JournalMini-Reviews in Medicinal Chemistry
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 1 2010

Keywords

  • Amino acids
  • Chiral derivatizing agents (CDAs)
  • Chiral stationary phases (CSPs)
  • Chirality
  • Enantiomers
  • High-performance liquid chromatography
  • Peptide epimers

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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