High-performance liquid chromatographic separation of enantiomers of 1,1'-binaphthyl-substituted α-aminoisobutyric acid

A. Péter, Gabriella Török, Jean Paul Mazaleyrat, Michel Wakselman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The direct and indirect stereochemical resolution of the enantiomers of free and N-protected (R,S)-2',1':1,2;1',2':3,4-dinaphthcyclohepta-1,3-diene- 6-amino-6-carboxylic acid (Bin) was achieved by high-performance liquid chromatographic methods. The direct separation was carded out on a β- cyclodextrin-based chiral stationary phase, ChiraDex, and the indirect resolution by applying pro-column derivatization with 2,3,4,6-tetra-O- acetyl-β-D-glucopyranosyl isothiocyanate.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalJournal of Chromatography A
Volume790
Issue number1-2
DOIs
Publication statusPublished - Nov 28 1997

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Aminoisobutyric Acids
Enantiomers
Cyclodextrins
Bins
Carboxylic Acids
Liquids
1,1'-binaphthyl
isothiocyanic acid

Keywords

  • Aminoisobutyric acid
  • Binaphthyl substituted
  • Enantiomer separation
  • Glycines

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

High-performance liquid chromatographic separation of enantiomers of 1,1'-binaphthyl-substituted α-aminoisobutyric acid. / Péter, A.; Török, Gabriella; Mazaleyrat, Jean Paul; Wakselman, Michel.

In: Journal of Chromatography A, Vol. 790, No. 1-2, 28.11.1997, p. 41-46.

Research output: Contribution to journalArticle

Péter, A. ; Török, Gabriella ; Mazaleyrat, Jean Paul ; Wakselman, Michel. / High-performance liquid chromatographic separation of enantiomers of 1,1'-binaphthyl-substituted α-aminoisobutyric acid. In: Journal of Chromatography A. 1997 ; Vol. 790, No. 1-2. pp. 41-46.
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