High-performance liquid chromatographic separation of enantiomers of 1,1'-binaphthyl-substituted α-aminoisobutyric acid

Antal Péter, Gabriella Török, Jean Paul Mazaleyrat, Michel Wakselman

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The direct and indirect stereochemical resolution of the enantiomers of free and N-protected (R,S)-2',1':1,2;1',2':3,4-dinaphthcyclohepta-1,3-diene- 6-amino-6-carboxylic acid (Bin) was achieved by high-performance liquid chromatographic methods. The direct separation was carded out on a β- cyclodextrin-based chiral stationary phase, ChiraDex, and the indirect resolution by applying pro-column derivatization with 2,3,4,6-tetra-O- acetyl-β-D-glucopyranosyl isothiocyanate.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalJournal of Chromatography A
Issue number1-2
Publication statusPublished - Nov 28 1997



  • Aminoisobutyric acid
  • Binaphthyl substituted
  • Enantiomer separation
  • Glycines

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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