High-performance liquid chromatographic retention behaviour of ring-substituted aniline derivatives on a porous graphitized carbon column

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Abstract

The retentions of sixteen ring-substituted aniline derivatives were determined on a graphitized carbon column using unbuffered acetonitrile-water and methanol-water eluent mixtures at various organic phase concentrations. Principal component analysis calculated from both the correlation and covariance matrices was used to detect the similarities and dissimilarities between the retention behaviours of the aniline derivatives. Each aniline derivative showed narrow and symmetrical peaks in each eluent. The high percentage of variance explained in the first principal component suggests that the eluents have common elution characteristics, but according to the second principal component they showed slightly different selectivities. The retention of aniline derivatives is not governed by their lipopholicity and bulkiness. The data indicate that a mixed type of retention mechanism accounts for the retention.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalJournal of Chromatography A
Volume600
Issue number1
DOIs
Publication statusPublished - May 27 1992

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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