High-performance liquid chromatographic enantioseparation of aminonaphthol analogs on polysaccharide-based chiral stationary phases

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12 Citations (Scopus)

Abstract

High-performance liquid chromatographic methods were developed for the separation of the enantiomers of five new aminonaphthol analogs possessing two chiral centers. The direct separations were performed on chiral stationary phases containing either amylose-tris-3,5-dimethylphenyl carbamate (Kromasil® AmyCoatTM column) or cellulose-tris-3,5-dimethylphenyl carbamate (Kromasil® CelluCoatTM column) as chiral selector. The experimental data are utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on the retention and separation. The elution sequence was determined in all cases; no general regularities could be established.

Original languageEnglish
Pages (from-to)2980-2985
Number of pages6
JournalJournal of Chromatography A
Volume1217
Issue number17
DOIs
Publication statusPublished - Apr 2010

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Amylose
Carbamates
Polysaccharides
Liquids
Enantiomers
Phase composition
cellulose tris-3,5-dimethylphenyl-carbamate

Keywords

  • Aminonaphthol analogs
  • AmyCoat TM column
  • CelluCoat TM column
  • Column liquid chromatography
  • Enantiomer separation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Biochemistry
  • Medicine(all)

Cite this

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title = "High-performance liquid chromatographic enantioseparation of aminonaphthol analogs on polysaccharide-based chiral stationary phases",
abstract = "High-performance liquid chromatographic methods were developed for the separation of the enantiomers of five new aminonaphthol analogs possessing two chiral centers. The direct separations were performed on chiral stationary phases containing either amylose-tris-3,5-dimethylphenyl carbamate (Kromasil{\circledR} AmyCoatTM column) or cellulose-tris-3,5-dimethylphenyl carbamate (Kromasil{\circledR} CelluCoatTM column) as chiral selector. The experimental data are utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on the retention and separation. The elution sequence was determined in all cases; no general regularities could be established.",
keywords = "Aminonaphthol analogs, AmyCoat TM column, CelluCoat TM column, Column liquid chromatography, Enantiomer separation",
author = "I. Ilisz and Zolt{\'a}n Pataj and R. Berkecz and I. Szatm{\'a}ri and F. F{\"u}l{\"o}p and A. P{\'e}ter",
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T1 - High-performance liquid chromatographic enantioseparation of aminonaphthol analogs on polysaccharide-based chiral stationary phases

AU - Ilisz, I.

AU - Pataj, Zoltán

AU - Berkecz, R.

AU - Szatmári, I.

AU - Fülöp, F.

AU - Péter, A.

PY - 2010/4

Y1 - 2010/4

N2 - High-performance liquid chromatographic methods were developed for the separation of the enantiomers of five new aminonaphthol analogs possessing two chiral centers. The direct separations were performed on chiral stationary phases containing either amylose-tris-3,5-dimethylphenyl carbamate (Kromasil® AmyCoatTM column) or cellulose-tris-3,5-dimethylphenyl carbamate (Kromasil® CelluCoatTM column) as chiral selector. The experimental data are utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on the retention and separation. The elution sequence was determined in all cases; no general regularities could be established.

AB - High-performance liquid chromatographic methods were developed for the separation of the enantiomers of five new aminonaphthol analogs possessing two chiral centers. The direct separations were performed on chiral stationary phases containing either amylose-tris-3,5-dimethylphenyl carbamate (Kromasil® AmyCoatTM column) or cellulose-tris-3,5-dimethylphenyl carbamate (Kromasil® CelluCoatTM column) as chiral selector. The experimental data are utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on the retention and separation. The elution sequence was determined in all cases; no general regularities could be established.

KW - Aminonaphthol analogs

KW - AmyCoat TM column

KW - CelluCoat TM column

KW - Column liquid chromatography

KW - Enantiomer separation

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