High-performance liquid chromatographic enantioseparation of β-3-homo-amino acid stereoisomers on a (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phase

Róbert Berkecz, István Ilisz, Ferenc Fülöp, Zoltán Pataj, Myung Ho Hyun, Antal Péter

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

High-performance liquid chromatographic methods were developed for the separation of the enantiomers of thirteen unusual β-3-homo-amino acids and three of its ethyl esters on a chiral stationary phase containing (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid as chiral selector. The effects of the mobile phase composition and the acidic modifiers on the separation were investigated. The structures of the substituents in β-position substantially influenced the retention and enantioseparation. The influence of ionic strength on the enantioseparation was established experimentally. The elution sequence was determined in all cases.

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalJournal of Chromatography A
Volume1189
Issue number1-2
DOIs
Publication statusPublished - May 2 2008

Keywords

  • (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phase
  • Column liquid chromatography
  • β-3-Homo-amino acids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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