High normal serum levels of C3 and C1 inhibitor, two acute-phase proteins belonging to the complement system, occur more frequently in patients with Crohn's disease than ulcerative colitis

L. Bene, G. Füst, B. Fekete, A. Kovács, L. Horváth, Z. Prohászka, Kata Miklós, Gábor Pálos, Mohamed Daha, H. Farkas, L. Varga

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Abstract

Few data are available on measurements of serum concentrations of complement proteins in inflammatory bowel disease (IBD). Therefore we measured serum levels of C3, C4, and C1-esterase inhibitor (C1-INH) as well as C-reactive protein (CRP) in 167 patients with Crohn's disease (CD) and 111 patients with ulcerative colitis (UC). Median serum concentrations of C3 and C1-INH were significantly higher in CD than in UC. According to multiple logistic regression analysis adjusted to age, sex, activity of disease, and presence of extraintestinal manifestations, IBD patients with high-normal (≥ 128%, ≥75th percentile) C1-INH concentrations had significantly (0.0275) higher odds ratio to have a diagnosis of CD than UC. Patients with high-normal C3 (≥ 1.40 g/liter) and high (≥20 mg/liter) CRP concentrations had an even higher odds ratio of a CD diagnosis (P = 0.0132). Our findings indicate that measurement of C3, C 1-INH, and CRP can be used as an additional marker to pANCA/ASCA for distinguishing patients with CD and UC.

Original languageEnglish
Pages (from-to)1186-1192
Number of pages7
JournalDigestive Diseases and Sciences
Volume48
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

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Acute-Phase Proteins
Ulcerative Colitis
Crohn Disease
Complement C1 Inhibitor Protein
C-Reactive Protein
Serum
Inflammatory Bowel Diseases
Odds Ratio
Complement System Proteins
Logistic Models
Regression Analysis

Keywords

  • C-reactive protein
  • Complement
  • Crohn's disease
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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title = "High normal serum levels of C3 and C1 inhibitor, two acute-phase proteins belonging to the complement system, occur more frequently in patients with Crohn's disease than ulcerative colitis",
abstract = "Few data are available on measurements of serum concentrations of complement proteins in inflammatory bowel disease (IBD). Therefore we measured serum levels of C3, C4, and C1-esterase inhibitor (C1-INH) as well as C-reactive protein (CRP) in 167 patients with Crohn's disease (CD) and 111 patients with ulcerative colitis (UC). Median serum concentrations of C3 and C1-INH were significantly higher in CD than in UC. According to multiple logistic regression analysis adjusted to age, sex, activity of disease, and presence of extraintestinal manifestations, IBD patients with high-normal (≥ 128{\%}, ≥75th percentile) C1-INH concentrations had significantly (0.0275) higher odds ratio to have a diagnosis of CD than UC. Patients with high-normal C3 (≥ 1.40 g/liter) and high (≥20 mg/liter) CRP concentrations had an even higher odds ratio of a CD diagnosis (P = 0.0132). Our findings indicate that measurement of C3, C 1-INH, and CRP can be used as an additional marker to pANCA/ASCA for distinguishing patients with CD and UC.",
keywords = "C-reactive protein, Complement, Crohn's disease, Inflammatory bowel disease, Ulcerative colitis",
author = "L. Bene and G. F{\"u}st and B. Fekete and A. Kov{\'a}cs and L. Horv{\'a}th and Z. Proh{\'a}szka and Kata Mikl{\'o}s and G{\'a}bor P{\'a}los and Mohamed Daha and H. Farkas and L. Varga",
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T1 - High normal serum levels of C3 and C1 inhibitor, two acute-phase proteins belonging to the complement system, occur more frequently in patients with Crohn's disease than ulcerative colitis

AU - Bene, L.

AU - Füst, G.

AU - Fekete, B.

AU - Kovács, A.

AU - Horváth, L.

AU - Prohászka, Z.

AU - Miklós, Kata

AU - Pálos, Gábor

AU - Daha, Mohamed

AU - Farkas, H.

AU - Varga, L.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Few data are available on measurements of serum concentrations of complement proteins in inflammatory bowel disease (IBD). Therefore we measured serum levels of C3, C4, and C1-esterase inhibitor (C1-INH) as well as C-reactive protein (CRP) in 167 patients with Crohn's disease (CD) and 111 patients with ulcerative colitis (UC). Median serum concentrations of C3 and C1-INH were significantly higher in CD than in UC. According to multiple logistic regression analysis adjusted to age, sex, activity of disease, and presence of extraintestinal manifestations, IBD patients with high-normal (≥ 128%, ≥75th percentile) C1-INH concentrations had significantly (0.0275) higher odds ratio to have a diagnosis of CD than UC. Patients with high-normal C3 (≥ 1.40 g/liter) and high (≥20 mg/liter) CRP concentrations had an even higher odds ratio of a CD diagnosis (P = 0.0132). Our findings indicate that measurement of C3, C 1-INH, and CRP can be used as an additional marker to pANCA/ASCA for distinguishing patients with CD and UC.

AB - Few data are available on measurements of serum concentrations of complement proteins in inflammatory bowel disease (IBD). Therefore we measured serum levels of C3, C4, and C1-esterase inhibitor (C1-INH) as well as C-reactive protein (CRP) in 167 patients with Crohn's disease (CD) and 111 patients with ulcerative colitis (UC). Median serum concentrations of C3 and C1-INH were significantly higher in CD than in UC. According to multiple logistic regression analysis adjusted to age, sex, activity of disease, and presence of extraintestinal manifestations, IBD patients with high-normal (≥ 128%, ≥75th percentile) C1-INH concentrations had significantly (0.0275) higher odds ratio to have a diagnosis of CD than UC. Patients with high-normal C3 (≥ 1.40 g/liter) and high (≥20 mg/liter) CRP concentrations had an even higher odds ratio of a CD diagnosis (P = 0.0132). Our findings indicate that measurement of C3, C 1-INH, and CRP can be used as an additional marker to pANCA/ASCA for distinguishing patients with CD and UC.

KW - C-reactive protein

KW - Complement

KW - Crohn's disease

KW - Inflammatory bowel disease

KW - Ulcerative colitis

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