High mitotic index associated with poor prognosis in gastrointestinal autonomic nerve tumour

T. Tornóczky, E. Kálmán, G. Hegedûs, O. Horvath, Z. Sápi, L. Antal, P. Jáksó, L. Pajor

Research output: Contribution to journalArticle

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Abstract

Aims: Three gastrointestinal autonomic nerve tumours (GANT) were characterized by immunohistochemistry and flow cytometry. Two of the three cases occurred in the small intestine, while the third was found in the stomach. Besides the immunohistochemical and ultrastructural description, the aim of this study was to examine the relation between the known and accepted predictive factors (ploidy data, the S-phase fraction, the mitotic and MIB-1 index and the size of the tumour) and the survival of the patients. Methods and results: The immune profile showed that 3/3 cases were vimentin and NSE, 2/3 were synaptophysin and PGP 9.5 positive, while 1/3 also showed S100 positivity. Ultrastructurally, all the cases had dense core granules, one of them contained skenoid fibres. The flow cytometry revealed diploid DNA in all cases, however, significant differences could be seen in the proliferative activity of the individual neoplasms. Conclusions: In spite of the published data of gastrointestinal stromal tumours (GIST) generally, neither the MIB-1 index and the ploidy data nor the size of the primary turnout helped to predict the clinical progression of the examined GANTs. However, the high proliferative activity (57 mitoses/10 HPF) and the elevated S-phase fraction (24%) was associated with advanced, metastatic and recurring disease in case 3. On the basis of these three cases, high mitotic activity is the most reliable factor in predicting aggressive clinical behaviour.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalHistopathology
Volume35
Issue number2
DOIs
Publication statusPublished - 1999

Fingerprint

Mitotic Index
Ploidies
S Phase
Flow Cytometry
Synaptophysin
Gastrointestinal Stromal Tumors
Vimentin
Diploidy
Mitosis
Small Intestine
Neoplasms
Stomach
Immunohistochemistry
Survival
DNA
Plexosarcoma

Keywords

  • Flow cytometry
  • GANT
  • Gastrointestinal autonomic nerve tumour
  • Gastrointestinal stromal tumour
  • GIST
  • MIB-1 index
  • Mitosis count
  • Prognosis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

High mitotic index associated with poor prognosis in gastrointestinal autonomic nerve tumour. / Tornóczky, T.; Kálmán, E.; Hegedûs, G.; Horvath, O.; Sápi, Z.; Antal, L.; Jáksó, P.; Pajor, L.

In: Histopathology, Vol. 35, No. 2, 1999, p. 121-128.

Research output: Contribution to journalArticle

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AU - Antal, L.

AU - Jáksó, P.

AU - Pajor, L.

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