High lipoprotein (a) levels with predminance of high molecular weight apo(a) isoforms in patients with pulmonary embolism

A. Császár, I. Karádi, E. Juhasz, L. Romics

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Lipoprotein(a) (Lp(a)) may interact with the cellular components and protein co-factors of fibrinolysis. To evaluate the effect of Lp(a) in thromboembolic diseases of the venous system, we measured serum levels and the isoform distribution of apo(a) in 25 patients with pulmonary embolism (18 men, 7 women, aged 21-77 years). The control group was adjusted for sex and age (P = 0.189). Serum Lp(a) concentration was significantly higher in the study group (median: 9.3 vs. 43 mg dL-1). As the distribution of high and low molecular weight subtypes of apo(a) did not show any differences (P = 0.127) between the two groups, the elevated Lp(a) levels in patients with pulmonary embolism could not be attributed to the investigated kringle-4 polymorphism of the apo(a) gene and therefore other genetic or non-genetic implications are indicated.

Original languageEnglish
Pages (from-to)368-370
Number of pages3
JournalEuropean Journal of Clinical Investigation
Volume25
Issue number5
Publication statusPublished - 1995

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Lipoprotein(a)
Pulmonary Embolism
Protein Isoforms
Molecular Weight
Molecular weight
Kringles
Fibrinolysis
Polymorphism
Serum
Genes
Control Groups
Proteins

Keywords

  • Apolipoprotein(a) phenotype
  • Lipoprotein(a)
  • Pulmonary embolism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "High lipoprotein (a) levels with predminance of high molecular weight apo(a) isoforms in patients with pulmonary embolism",
abstract = "Lipoprotein(a) (Lp(a)) may interact with the cellular components and protein co-factors of fibrinolysis. To evaluate the effect of Lp(a) in thromboembolic diseases of the venous system, we measured serum levels and the isoform distribution of apo(a) in 25 patients with pulmonary embolism (18 men, 7 women, aged 21-77 years). The control group was adjusted for sex and age (P = 0.189). Serum Lp(a) concentration was significantly higher in the study group (median: 9.3 vs. 43 mg dL-1). As the distribution of high and low molecular weight subtypes of apo(a) did not show any differences (P = 0.127) between the two groups, the elevated Lp(a) levels in patients with pulmonary embolism could not be attributed to the investigated kringle-4 polymorphism of the apo(a) gene and therefore other genetic or non-genetic implications are indicated.",
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T1 - High lipoprotein (a) levels with predminance of high molecular weight apo(a) isoforms in patients with pulmonary embolism

AU - Császár, A.

AU - Karádi, I.

AU - Juhasz, E.

AU - Romics, L.

PY - 1995

Y1 - 1995

N2 - Lipoprotein(a) (Lp(a)) may interact with the cellular components and protein co-factors of fibrinolysis. To evaluate the effect of Lp(a) in thromboembolic diseases of the venous system, we measured serum levels and the isoform distribution of apo(a) in 25 patients with pulmonary embolism (18 men, 7 women, aged 21-77 years). The control group was adjusted for sex and age (P = 0.189). Serum Lp(a) concentration was significantly higher in the study group (median: 9.3 vs. 43 mg dL-1). As the distribution of high and low molecular weight subtypes of apo(a) did not show any differences (P = 0.127) between the two groups, the elevated Lp(a) levels in patients with pulmonary embolism could not be attributed to the investigated kringle-4 polymorphism of the apo(a) gene and therefore other genetic or non-genetic implications are indicated.

AB - Lipoprotein(a) (Lp(a)) may interact with the cellular components and protein co-factors of fibrinolysis. To evaluate the effect of Lp(a) in thromboembolic diseases of the venous system, we measured serum levels and the isoform distribution of apo(a) in 25 patients with pulmonary embolism (18 men, 7 women, aged 21-77 years). The control group was adjusted for sex and age (P = 0.189). Serum Lp(a) concentration was significantly higher in the study group (median: 9.3 vs. 43 mg dL-1). As the distribution of high and low molecular weight subtypes of apo(a) did not show any differences (P = 0.127) between the two groups, the elevated Lp(a) levels in patients with pulmonary embolism could not be attributed to the investigated kringle-4 polymorphism of the apo(a) gene and therefore other genetic or non-genetic implications are indicated.

KW - Apolipoprotein(a) phenotype

KW - Lipoprotein(a)

KW - Pulmonary embolism

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