High kinetic inertness of a bis-hydrated Gd-complex with a constrained AAZTA-like ligand

Adrienn Vágner, Eliana Gianolio, Silvio Aime, Alessandro Maiocchi, Imre Tóth, Zsolt Baranyai, Lorenzo Tei

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Kinetic inertness is a key property for a Gd-based contrast agent. The GdIII complex of a cyclohexyl-fused AAZTA derivative shows the highest kinetic inertness for non-macrocyclic bis hydrated (q = 2) GdIII-complexes with a dissociation half-life of 91 years under physiological conditions, very close to that of macrocyclic clinically approved contrast agents. It also shows optimal relaxometric performance (r1 = 8.3 mM-1 s-1 at 20 MHz and 25 °C) due to the presence of two inner sphere water molecules in fast exchange with bulk water and not displaced by endogenous anions.

Original languageEnglish
Pages (from-to)11235-11238
Number of pages4
JournalChemical Communications
Volume52
Issue number75
DOIs
Publication statusPublished - Jan 1 2016

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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