High-dose radiation induced heart damage in a rat model

Laura Kiscsatári, Márta Sárközy, Bence Kvári, Zoltán Varga, Kamilla Gömöri, Nikolett Morvay, István Leprán, Hargita Hegyesi, Gabriella Fábián, Bálint Cserni, G. Cserni, Tamás Csont, Zsuzsanna Kahán

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/Aim: Radiation-induced heart disease (RIHD) is a concern during radiotherapy. For its comprehensive study, an in vivo selective heart irradiation model was developed. Materials and Methods: Sprague-Dawley rats were irradiated with 50 Gy and functional imaging, biochemical (circulating growth differentiation factor-15 (GDF-15), transforming growth factor-beta (TGFbeta) and morphological (picrosirius red staining of the heart) objectives were tested. Results: Signs and symptoms of RIHD occurred >12 weeks after irradiation with tachypnea, systolic and diastolic dysfunction, cardiac hypertrophy and body development retardation. Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation. At autopsy, extensive pleural fluid was found in the irradiated animals. Interstitial fibrosis could be reliably detected and quantified in irradiated hearts after a follow-up time of 19 weeks. Conclusion: The studied parameters could be used in future experiments for testing protective agents for prevention of radiation heart injury.

Original languageEnglish
Pages (from-to)623-631
Number of pages9
JournalIn Vivo
Volume30
Issue number5
Publication statusPublished - Sep 1 2016

Fingerprint

Growth Differentiation Factor 15
Dosimetry
Rats
Radiation
Transforming Growth Factor beta
Heart Diseases
Heart Injuries
Background Radiation
Tachypnea
Protective Agents
Radiation Injuries
Cardiomegaly
Irradiation
Signs and Symptoms
Sprague Dawley Rats
Autopsy
Fibrosis
Radiotherapy
Staining and Labeling
Plasmas

Keywords

  • Heart function
  • Inflammatory cytokines
  • Radiation heart damage
  • Radiogenic fibrosis
  • Rat model

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Kiscsatári, L., Sárközy, M., Kvári, B., Varga, Z., Gömöri, K., Morvay, N., ... Kahán, Z. (2016). High-dose radiation induced heart damage in a rat model. In Vivo, 30(5), 623-631.

High-dose radiation induced heart damage in a rat model. / Kiscsatári, Laura; Sárközy, Márta; Kvári, Bence; Varga, Zoltán; Gömöri, Kamilla; Morvay, Nikolett; Leprán, István; Hegyesi, Hargita; Fábián, Gabriella; Cserni, Bálint; Cserni, G.; Csont, Tamás; Kahán, Zsuzsanna.

In: In Vivo, Vol. 30, No. 5, 01.09.2016, p. 623-631.

Research output: Contribution to journalArticle

Kiscsatári, L, Sárközy, M, Kvári, B, Varga, Z, Gömöri, K, Morvay, N, Leprán, I, Hegyesi, H, Fábián, G, Cserni, B, Cserni, G, Csont, T & Kahán, Z 2016, 'High-dose radiation induced heart damage in a rat model', In Vivo, vol. 30, no. 5, pp. 623-631.
Kiscsatári L, Sárközy M, Kvári B, Varga Z, Gömöri K, Morvay N et al. High-dose radiation induced heart damage in a rat model. In Vivo. 2016 Sep 1;30(5):623-631.
Kiscsatári, Laura ; Sárközy, Márta ; Kvári, Bence ; Varga, Zoltán ; Gömöri, Kamilla ; Morvay, Nikolett ; Leprán, István ; Hegyesi, Hargita ; Fábián, Gabriella ; Cserni, Bálint ; Cserni, G. ; Csont, Tamás ; Kahán, Zsuzsanna. / High-dose radiation induced heart damage in a rat model. In: In Vivo. 2016 ; Vol. 30, No. 5. pp. 623-631.
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