High-concentration piperine

Capsaicin-sensitive and-insensitive effects on isolated organs

Timea Bencsik, Zsolt Sandor, L. Barthó

Research output: Contribution to journalArticle

Abstract

Piperine (P), a sensory stimulant in black pepper, is an agonist on TRPV1 receptors. Earlier work has showed capsaicinsensitive and-insensitive mechanisms of the contractile action of P on the intestine. The current isolated organ study in the Guinea-pig ileum, urinary bladder and trachea (a) confirms the presence of such components of effect (ileum and bladder); (b) indicates TRPV1 involvement in the effect of 5 or 30 mol/l of P on the basis of an inhibitory action of the antagonist BCTC (ileum); (c) indicates that HC 030031-sensitive TRPA1 receptors and nifedipine-sensitive Ca 2+ channels contribute to the capsaicin-resistant contraction to 30 mol/l P (ileum) and (d) shows that the contractile effect of P up to 100 mol/l (Guinea-pig trachea) or 30 mol/l (Guinea-pig urinary bladder) is capsaicin-sensitive and mediated by TRPV1 receptors/channels.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalPharmacology
Volume96
Issue number1-2
DOIs
Publication statusPublished - Aug 20 2015

Fingerprint

piperine
Capsaicin
Ileum
Guinea Pigs
Urinary Bladder
Trachea
Piper nigrum
Nifedipine
Intestines

Keywords

  • Bladder
  • Contraction
  • Guinea-pig
  • Ileum
  • Piperine
  • Trachea
  • TRPA1
  • TRPV1

ASJC Scopus subject areas

  • Pharmacology

Cite this

High-concentration piperine : Capsaicin-sensitive and-insensitive effects on isolated organs. / Bencsik, Timea; Sandor, Zsolt; Barthó, L.

In: Pharmacology, Vol. 96, No. 1-2, 20.08.2015, p. 86-89.

Research output: Contribution to journalArticle

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