High-concentration piperine: Capsaicin-sensitive and-insensitive effects on isolated organs

Timea Bencsik, Zsolt Sandor, Lorand Bartho

Research output: Contribution to journalArticle


Piperine (P), a sensory stimulant in black pepper, is an agonist on TRPV1 receptors. Earlier work has showed capsaicinsensitive and-insensitive mechanisms of the contractile action of P on the intestine. The current isolated organ study in the Guinea-pig ileum, urinary bladder and trachea (a) confirms the presence of such components of effect (ileum and bladder); (b) indicates TRPV1 involvement in the effect of 5 or 30 mol/l of P on the basis of an inhibitory action of the antagonist BCTC (ileum); (c) indicates that HC 030031-sensitive TRPA1 receptors and nifedipine-sensitive Ca 2+ channels contribute to the capsaicin-resistant contraction to 30 mol/l P (ileum) and (d) shows that the contractile effect of P up to 100 mol/l (Guinea-pig trachea) or 30 mol/l (Guinea-pig urinary bladder) is capsaicin-sensitive and mediated by TRPV1 receptors/channels.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
Issue number1-2
Publication statusPublished - Aug 20 2015



  • Bladder
  • Contraction
  • Guinea-pig
  • Ileum
  • Piperine
  • TRPA1
  • TRPV1
  • Trachea

ASJC Scopus subject areas

  • Pharmacology

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