High circulating osteoprotegerin levels are associated with non-zero blood groups

Elod Erno Nagy, Timea Varga-Fekete, Attila Puskas, Piroska Kelemen, Zoltan Brassai, Katalin Szekeres-Csiki, Timea Gombos, Maria Csilla Csanyi, Jolan Harsfalvi

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Background: Osteoprotegerin (OPG) and von Willebrand factor (VWF) form complex within endothelial cells and following secretion. The nature of blood group antigens strongly influences the levels of circulating VWF, but there is no available data concerning its ascendancy on OPG levels. We aimed to assess the relationship of AB0 blood groups with OPG, VWF levels (VWF: Ag) and collagen binding activity (VWF: CB) in peripheral arterial disease (PAD) patients. Methods: Functional and laboratory parameters of 105 PAD patients and 109 controls were examined. Results of OPG, VWF: Ag, VWF: CB (ELISA-s) were analysed by comparative statistics, together with clinical data. Results: OPG levels were higher in patients than in controls (4.64 ng/mL vs. 3.68 ng/mL, p < 0.001). Among patients elevation was marked in the presence of critical limb ischemia (5.19 ng/mL vs. 4.20 ng/mL, p = 0.011). The OPG in patients correlated positively with VWF: Ag and VWF: CB (r = 0.26, p = 0.008; r = 0.33, p = 0.001) and negatively with ankle-brachial pressure index (r = -0.22, p = 0.023). Furthermore, OPG was significantly elevated in non-0 blood groups compared to 0-groups both in patients and controls (4.95 ng/mL vs. 3.90 ng/mL, p = 0.012 and 4.09 ng/mL vs. 3.40 ng/mL, p = 0.002). Conclusions: OPG levels are associated to blood group phenotypes and higher in non-0 individuals. Increased OPG levels in PAD characterize disease severity. The significant correlation between OPG and VWF:CB might have functional importance in an atherothrombosis-prone biological environment.

Original languageEnglish
Article number106
JournalBMC cardiovascular disorders
Issue number1
Publication statusPublished - 2016


  • AB0 blood groups
  • Atherosclerosis
  • Atherosclerosis
  • Critical ischemia
  • Diabetes
  • Endothelial dysfunction
  • Hypertension
  • Osteoprotegerin
  • Peripheral arterial disease
  • Von Willebrand factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Nagy, E. E., Varga-Fekete, T., Puskas, A., Kelemen, P., Brassai, Z., Szekeres-Csiki, K., Gombos, T., Csanyi, M. C., & Harsfalvi, J. (2016). High circulating osteoprotegerin levels are associated with non-zero blood groups. BMC cardiovascular disorders, 16(1), [106]. https://doi.org/10.1186/s12872-016-0287-2