High anxiety and migraine are associated with the s allele of the 5HTTLPR gene polymorphism

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Abstract

The 5HTTLPR polymorphism of the serotonin transporter gene has been associated with anxiety disorders and also migraine, suggesting a common etiological background of these disorders. This association is further supported by the high comorbidity of these disorders. In our study Spielberger's State-Trait Anxiety Inventory and the 5HTTLPR genotype were investigated in a cohort of 97 psychiatrically healthy females also including 45 migraineurs. Higher state anxiety scores were significantly associated with the s allele either in the whole sample or when the group was separated into migraineurs and non-migraineurs. Migraineurs also had a significantly higher frequency of the s allele. Our results indicate that even in a healthy population the s allele is associated with a high anxiety endophenotype. The association of migraine with anxiety may be explained by the higher rate of individuals carrying the s allele among migraineurs.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalPsychiatry research
Volume149
Issue number1-3
DOIs
Publication statusPublished - Jan 15 2007

Keywords

  • Anxiety
  • Endophenotype
  • Migraine
  • Polymorphism
  • Serotonin transporter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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