High anti-paternal cytotoxic T-lymphocyte precursor frequencies in women with unexplained recurrent spontaneous abortions

Beatrix Kotlan, Vilmos Fülöp, Ágnes Padányi, Iván Szigetvári, Marienn Réti, Éva Gyódi, Éva Fehér, Gyözö Petrányi

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17 Citations (Scopus)


A number of cases of unexplained (idiopathic) recurrent spontaneous abortions may be attributable to immunological mechanisms. Several lines of evidence indicate that some immunocompetent effector cell populations play an important role in the pathogenesis of unexplained miscarriages. However a suitable method is lacking for defining an existing immunological background of recurrent spontaneous abortions. We tried to find a useful cellular immunological method, that is suitable for predicting the eventual immunological cause in the case of unexplained recurrent spontaneous abortions. We have examined the anti-paternal cytotoxic T-lymphocyte precursor frequencies by cell-mediated lympholysis and limiting dilution analysis in the peripheral blood of women with recurrent spontaneous abortions in order to reveal the functional role of this cell population in spontaneous abortions. An extremely high partner allo-antigen-specific cytotoxic T-lymphocyte precursor frequency was determined in the case of all those habitual aborters, where no other than an immunological cause could be responsible for the abortions. This phenomenon supports the important role of the T-lymphocytes in this disorder. We suggest that the immunological background of recurrent spontaneous miscarriages might be determined on the basis of a very high cytotoxic T-lymphocyte precursor frequency. This diagnostic test might be useful in selecting patients for immunotherapy.

Original languageEnglish
Pages (from-to)1278-1285
Number of pages8
JournalHuman Reproduction
Issue number6
Publication statusPublished - Jan 1 2001



  • Cytotoxic T-lymphocyte precursors
  • Immunological background
  • Recurrent spontaneous abortion

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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