High ABCG4 expression is associated with poor prognosis in non-small-cell lung cancer patients treated with cisplatin-based chemotherapy

Guang Yang, Xue Jiao Wang, Li Jun Huang, Yong An Zhou, Feng Tian, Jin Bo Zhao, Peng Chen, Bo Ya Liu, Miao Miao Wen, Xiao Fei Li, Zhi Pei Zhang, G. Szakács

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

ATP-binding cassette (ABC) transporters are associated with poor response to chemotherapy, and confer a poor prognosis in various malignancies. However, the association between the expression of the ABC sub-family G member 4 (ABCG4) and prognosis in patients with non-small-cell lung cancer (NSCLC) remains unclear. NSCLC tissue samples (n = 140) and normal lung tissue samples (n = 90) were resected from patients with stage II to IV NSCLC between May 2004 and May 2009. ABCG4 mRNA and protein expressions were detected by RT-PCR, western blot, and immunohistochemistry. Patients received four cycles of cisplatin-based post-surgery chemotherapy and were followed up until May 31st, 2014. ABCG4 positivity rate was higher in NSCLC than in normal lung tissues (48.6% vs. 0%, P

Original languageEnglish
Article numbere0135576
JournalPLoS One
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 13 2015

Fingerprint

cisplatin
Chemotherapy
lung neoplasms
Non-Small Cell Lung Carcinoma
Cisplatin
prognosis
drug therapy
Cells
Tissue
Drug Therapy
ATP-Binding Cassette Transporters
lungs
cells
Lung
Surgery
ABC transporters
Adenosine Triphosphate
immunohistochemistry
Messenger RNA
Western blotting

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

High ABCG4 expression is associated with poor prognosis in non-small-cell lung cancer patients treated with cisplatin-based chemotherapy. / Yang, Guang; Wang, Xue Jiao; Huang, Li Jun; Zhou, Yong An; Tian, Feng; Zhao, Jin Bo; Chen, Peng; Liu, Bo Ya; Wen, Miao Miao; Li, Xiao Fei; Zhang, Zhi Pei; Szakács, G.

In: PLoS One, Vol. 10, No. 8, e0135576, 13.08.2015.

Research output: Contribution to journalArticle

Yang, G, Wang, XJ, Huang, LJ, Zhou, YA, Tian, F, Zhao, JB, Chen, P, Liu, BY, Wen, MM, Li, XF, Zhang, ZP & Szakács, G 2015, 'High ABCG4 expression is associated with poor prognosis in non-small-cell lung cancer patients treated with cisplatin-based chemotherapy', PLoS One, vol. 10, no. 8, e0135576. https://doi.org/10.1371/journal.pone.0135576
Yang, Guang ; Wang, Xue Jiao ; Huang, Li Jun ; Zhou, Yong An ; Tian, Feng ; Zhao, Jin Bo ; Chen, Peng ; Liu, Bo Ya ; Wen, Miao Miao ; Li, Xiao Fei ; Zhang, Zhi Pei ; Szakács, G. / High ABCG4 expression is associated with poor prognosis in non-small-cell lung cancer patients treated with cisplatin-based chemotherapy. In: PLoS One. 2015 ; Vol. 10, No. 8.
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