Hierarchical modelling in biology: Systematic building of limb models

C. S. Fazekas, G. Y. Kozmann, K. M. Hangos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A multi-level model, that provides a hierarchically structured description of a complex, multi-scale limb system is proposed in this paper for predicting and analyzing movement patters generated by various activation signals. The levels, the sub-models on each level and their interconnections are developed and described following a systematic modelling procedure. The computational properties (degree of freedom and differential index) of the developed model have been analyzed and a sub-model has been transformed to meet the index-one requirement for solving the resulting differential algebraic equation (DAE) model by standard methods implemented in MATLAB. The model is extensively verified against engineering expectations using parameter values found in the literature, and a good agreement was found. Parameter sensitivity analysis has also been performed.

Original languageEnglish
Title of host publicationProceedings of the 16th IFAC World Congress, IFAC 2005
PublisherIFAC Secretariat
Pages49-54
Number of pages6
Edition1
ISBN (Print)008045108X, 9780080451084
DOIs
Publication statusPublished - Jan 1 2005

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
Number1
Volume38
ISSN (Print)1474-6670

Keywords

  • Aponeurosis
  • Biomedical system
  • Hierarchical system
  • Model
  • Muscle
  • Pennation
  • Sarcomere
  • Tendon

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Fazekas, C. S., Kozmann, G. Y., & Hangos, K. M. (2005). Hierarchical modelling in biology: Systematic building of limb models. In Proceedings of the 16th IFAC World Congress, IFAC 2005 (1 ed., pp. 49-54). (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 38, No. 1). IFAC Secretariat. https://doi.org/10.3182/20050703-6-cz-1902.02122