Hexose-6-phosphate dehydrogenase: Linking endocrinology and metabolism in the endoplasmic reticulum

G. Bánhegyi, M. Csala, Angelo Benedetti

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Hexose-6-phosphate dehydrogenase (H6PD) got into the focus of interest due to its role in the prereceptorial activation of glucocorticoids, which has been implicated in the pathomechanism of metabolic syndrome. Genetic observations, results gained in H6PD knockout mice, and studies on differentiating adipocytes demonstrated the importance of the enzyme in metabolic regulation. A nutrient-sensing function can be postulated for the enzyme, which links metabolism to endocrinology in the endoplasmic reticulum. This review provides an overview of the recent developments concerning the enzyme and its impact on various branches of the intermediary metabolism, which make it an important subject for the research on obesity, diabetes, and metabolic syndrome.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalJournal of Molecular Endocrinology
Volume42
Issue number4
DOIs
Publication statusPublished - 2009

Fingerprint

Endocrinology
Endoplasmic Reticulum
Enzymes
Adipocytes
Knockout Mice
Glucocorticoids
Obesity
Food
Research
galactose-6-phosphate dehydrogenase

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology

Cite this

Hexose-6-phosphate dehydrogenase : Linking endocrinology and metabolism in the endoplasmic reticulum. / Bánhegyi, G.; Csala, M.; Benedetti, Angelo.

In: Journal of Molecular Endocrinology, Vol. 42, No. 4, 2009, p. 283-289.

Research output: Contribution to journalArticle

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