Hexose-6-phosphate dehydrogenase in the endoplasmic reticulum

Silvia Senesi, M. Csala, Paola Marcolongo, Rosella Fulceri, J. Mandl, G. Bánhegyi, Angelo Benedetti

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Hexose-6-phosphate dehydrogenase (H6PD) is a luminal enzyme of the endoplasmic reticulum that is distinguished from cytosolic glucose-6-phosphate dehydrogenase by several features. H6PD converts glucose-6-phosphate and NADP+ to 6-phosphogluconate and NADPH, thereby catalyzing the first two reactions of the pentose-phosphate pathway. Because the endoplasmic reticulum has a separate pyridine nucleotide pool, H6PD provides NADPH for luminal reductases. One of these enzymes, 11β-hydroxysteroid dehydrogenase type 1 responsible for prereceptorial activation of glucocorticoids, has been the focus of much attention as a probable factor in the pathomechanism of several human diseases including insulin resistance and the metabolic syndrome. This review summarizes recent advances related to the functions of H6PD.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBiological Chemistry
Volume391
Issue number1
DOIs
Publication statusPublished - Jan 1 2010

Fingerprint

Endoplasmic Reticulum
NADP
11-beta-Hydroxysteroid Dehydrogenases
Pentoses
Pentose Phosphate Pathway
Glucose-6-Phosphate
Glucosephosphate Dehydrogenase
Enzymes
Glucocorticoids
Insulin Resistance
Oxidoreductases
Nucleotides
Chemical activation
Phosphates
Insulin
galactose-6-phosphate dehydrogenase

Keywords

  • 11β-hydroxysteroid dehydrogenase type 1
  • Apparent cortisone reductase deficiency
  • Glucocorticoids
  • Glucose-6-phosphate
  • NADPH

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology

Cite this

Hexose-6-phosphate dehydrogenase in the endoplasmic reticulum. / Senesi, Silvia; Csala, M.; Marcolongo, Paola; Fulceri, Rosella; Mandl, J.; Bánhegyi, G.; Benedetti, Angelo.

In: Biological Chemistry, Vol. 391, No. 1, 01.01.2010, p. 1-8.

Research output: Contribution to journalArticle

Senesi, Silvia ; Csala, M. ; Marcolongo, Paola ; Fulceri, Rosella ; Mandl, J. ; Bánhegyi, G. ; Benedetti, Angelo. / Hexose-6-phosphate dehydrogenase in the endoplasmic reticulum. In: Biological Chemistry. 2010 ; Vol. 391, No. 1. pp. 1-8.
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