Heterogenous inositol tetrakisphosphate binding sites in the adrenal cortex

P. Enyedi, G. H. Williams

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Bovine adrenal cortical microsomes possess high (K(d) = 3.68 ± 1.02 x 10-9 M) and lower (K(d) = 9.20 ± 1.71 x 10-8 M) affinity binding sites for inositol 1,3,4,5-tetrakisphosphate. The binding to these sites is rapid, saturable (reaches equilibrium by 15 min at 0°C), and reversible. Competition studies with other inositol phosphate analogs indicate that the high affinity binding sites are clearly distinct from the inositol 1,4,5-trisphosphate receptors which are, however, responsible for a fraction of the lower affinity binding. The characteristics of the inositol 1,3,4,5-tetrakisphosphate binding sites described are compatible with their possible receptor function.

Original languageEnglish
Pages (from-to)7940-7942
Number of pages3
JournalJournal of Biological Chemistry
Volume263
Issue number17
Publication statusPublished - Jan 1 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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