Heterogeneous asymmetric reactions part 25. On the pretreatment and prehydrogenation of Pt-alumina catalyst in the hydrogenation of ethyl pyruvate

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Abstract

The effect of the prehydrogenation on the enantioselective hydrogenation of ethyl pyruvate on the Pt-alumina catalyst (Engelhard 4759) pretreated in hydrogen at 673 K was studied by ESI-MS. It was established that in the concentration range used the hydrogenation of the quinoline skeleton of cinchonidine and dihydrocinchonidine takes place under relatively mild conditions (room temperature, 1 bar H2 pressure), leading to a decrease in the optical yield attained (90%). In order to avoid this, it is necessary to prehydrogenate the pretreated catalyst in the absence of modifier and hydrogenation of ethyl pyruvate must be stopped approximately at 70% conversion.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalJournal of Molecular Catalysis A: Chemical
Volume177
Issue number2
DOIs
Publication statusPublished - Jan 10 2002

Keywords

  • Cinchonidine
  • Enantioselective
  • Ethyl pyruvate
  • Hydrogenation
  • Platinum-alumina
  • Prehydrogenation
  • Pretreatment

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology
  • Physical and Theoretical Chemistry

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