Heterogeneous asymmetric reactions part 25. On the pretreatment and prehydrogenation of Pt-alumina catalyst in the hydrogenation of ethyl pyruvate

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The effect of the prehydrogenation on the enantioselective hydrogenation of ethyl pyruvate on the Pt-alumina catalyst (Engelhard 4759) pretreated in hydrogen at 673 K was studied by ESI-MS. It was established that in the concentration range used the hydrogenation of the quinoline skeleton of cinchonidine and dihydrocinchonidine takes place under relatively mild conditions (room temperature, 1 bar H2 pressure), leading to a decrease in the optical yield attained (90%). In order to avoid this, it is necessary to prehydrogenate the pretreated catalyst in the absence of modifier and hydrogenation of ethyl pyruvate must be stopped approximately at 70% conversion.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalJournal of Molecular Catalysis A: Chemical
Volume177
Issue number2
DOIs
Publication statusPublished - Jan 10 2002

Fingerprint

pyruvates
Aluminum Oxide
pretreatment
Hydrogenation
hydrogenation
Alumina
aluminum oxides
catalysts
Catalysts
quinoline
musculoskeletal system
Hydrogen
room temperature
hydrogen
ethyl pyruvate
Temperature

Keywords

  • Cinchonidine
  • Enantioselective
  • Ethyl pyruvate
  • Hydrogenation
  • Platinum-alumina
  • Prehydrogenation
  • Pretreatment

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology

Cite this

@article{6e3b3abdb8da4a80a8a9b6e38530f0b4,
title = "Heterogeneous asymmetric reactions part 25. On the pretreatment and prehydrogenation of Pt-alumina catalyst in the hydrogenation of ethyl pyruvate",
abstract = "The effect of the prehydrogenation on the enantioselective hydrogenation of ethyl pyruvate on the Pt-alumina catalyst (Engelhard 4759) pretreated in hydrogen at 673 K was studied by ESI-MS. It was established that in the concentration range used the hydrogenation of the quinoline skeleton of cinchonidine and dihydrocinchonidine takes place under relatively mild conditions (room temperature, 1 bar H2 pressure), leading to a decrease in the optical yield attained (90{\%}). In order to avoid this, it is necessary to prehydrogenate the pretreated catalyst in the absence of modifier and hydrogenation of ethyl pyruvate must be stopped approximately at 70{\%} conversion.",
keywords = "Cinchonidine, Enantioselective, Ethyl pyruvate, Hydrogenation, Platinum-alumina, Prehydrogenation, Pretreatment",
author = "M. Bart{\'o}k and G. Sz{\"o}llősi and K. Bal{\'a}zsik and T. Bart{\'o}k",
year = "2002",
month = "1",
day = "10",
doi = "10.1016/S1381-1169(01)00278-3",
language = "English",
volume = "177",
pages = "299--305",
journal = "Journal of Molecular Catalysis A: Chemical",
issn = "1381-1169",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Heterogeneous asymmetric reactions part 25. On the pretreatment and prehydrogenation of Pt-alumina catalyst in the hydrogenation of ethyl pyruvate

AU - Bartók, M.

AU - Szöllősi, G.

AU - Balázsik, K.

AU - Bartók, T.

PY - 2002/1/10

Y1 - 2002/1/10

N2 - The effect of the prehydrogenation on the enantioselective hydrogenation of ethyl pyruvate on the Pt-alumina catalyst (Engelhard 4759) pretreated in hydrogen at 673 K was studied by ESI-MS. It was established that in the concentration range used the hydrogenation of the quinoline skeleton of cinchonidine and dihydrocinchonidine takes place under relatively mild conditions (room temperature, 1 bar H2 pressure), leading to a decrease in the optical yield attained (90%). In order to avoid this, it is necessary to prehydrogenate the pretreated catalyst in the absence of modifier and hydrogenation of ethyl pyruvate must be stopped approximately at 70% conversion.

AB - The effect of the prehydrogenation on the enantioselective hydrogenation of ethyl pyruvate on the Pt-alumina catalyst (Engelhard 4759) pretreated in hydrogen at 673 K was studied by ESI-MS. It was established that in the concentration range used the hydrogenation of the quinoline skeleton of cinchonidine and dihydrocinchonidine takes place under relatively mild conditions (room temperature, 1 bar H2 pressure), leading to a decrease in the optical yield attained (90%). In order to avoid this, it is necessary to prehydrogenate the pretreated catalyst in the absence of modifier and hydrogenation of ethyl pyruvate must be stopped approximately at 70% conversion.

KW - Cinchonidine

KW - Enantioselective

KW - Ethyl pyruvate

KW - Hydrogenation

KW - Platinum-alumina

KW - Prehydrogenation

KW - Pretreatment

UR - http://www.scopus.com/inward/record.url?scp=0037050036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037050036&partnerID=8YFLogxK

U2 - 10.1016/S1381-1169(01)00278-3

DO - 10.1016/S1381-1169(01)00278-3

M3 - Article

AN - SCOPUS:0037050036

VL - 177

SP - 299

EP - 305

JO - Journal of Molecular Catalysis A: Chemical

JF - Journal of Molecular Catalysis A: Chemical

SN - 1381-1169

IS - 2

ER -