Heterogeneity of the blood-brain barrier

I. Wilhelm, Ádám Nyúl-Tóth, Maria Suciu, Anca Hermenean, I. Krizbai

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

ABSTRACT: The brain microvascular network is comprised of capillaries, arterioles and venules, all of which retain – although to a different extent – blood-brain barrier (BBB) properties. Capillaries constitute the largest and tightest microvasculature. In contrast, venules have a looser junctional arrangement, while arterioles have a lower expression of P-gp. Development and maintenance of the BBB depends on the interaction of cerebral endothelial cells with pericytes and astrocytes, which are all heterogeneous in different regions of the central nervous system. At the level of circumventricular organs microvessels are permeable, containing fenestrations and discontinuous tight junctions. In addition, the blood-spinal cord barrier – where the number of pericytes is lower and expression of junctional proteins is reduced – is also more permeable than the BBB. However, much less is known about the cellular, molecular and functional differences among other regions of the brain. This review summarizes our current knowledge on the heterogeneity of the brain microvasculature.

Original languageEnglish
JournalTissue Barriers
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2 2016

Fingerprint

Microvessels
Blood-Brain Barrier
Brain
Pericytes
Venules
Arterioles
Endothelial cells
Neurology
Tight Junctions
Blood
Astrocytes
Spinal Cord
Central Nervous System
Endothelial Cells
Maintenance
Proteins

Keywords

  • astrocytes
  • blood-brain barrier
  • blood-spinal cord barrier
  • cerebral endothelial cells
  • circumventricular organs
  • gray and white matter
  • microvessel
  • neurovascular unit
  • pericytes
  • regional differences

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Histology

Cite this

Heterogeneity of the blood-brain barrier. / Wilhelm, I.; Nyúl-Tóth, Ádám; Suciu, Maria; Hermenean, Anca; Krizbai, I.

In: Tissue Barriers, Vol. 4, No. 1, 02.01.2016.

Research output: Contribution to journalReview article

Wilhelm, I. ; Nyúl-Tóth, Ádám ; Suciu, Maria ; Hermenean, Anca ; Krizbai, I. / Heterogeneity of the blood-brain barrier. In: Tissue Barriers. 2016 ; Vol. 4, No. 1.
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