Heterogeneity of stem cells: A brief overview

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Stem cells possess the extraordinary capacity of self-renewal and differentiation to various cell types, thus to form original tissues and organs. Stem cell heterogeneity including genetic and nongenetic mechanisms refers to biological differences amongst normal and stem cells originated within the same tissue. Cell differentiation hierarchy and stochasticity in gene expression and signaling pathways may result in phenotypic differences of stem cells. The maintenance of stemness and activation of differentiation potential are fundamentally orchestrated by microenvironmental stem cell niche-related cellular and humoral signals.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Volume1516
DOIs
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1516
ISSN (Print)10643745

Fingerprint

Stem Cells
Stem Cell Niche
Genetic Heterogeneity
Cell Differentiation
Maintenance
Gene Expression

Keywords

  • Adult stem cells
  • Cancer stem cells
  • Differentiation
  • Embryonic stem cells
  • Induced pluripotent stem cells
  • Microenvironment

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Genetics

Cite this

Müzes, G., & Sípos, F. (2016). Heterogeneity of stem cells: A brief overview. In Methods in Molecular Biology (Vol. 1516). (Methods in Molecular Biology; Vol. 1516). Humana Press Inc.. https://doi.org/10.1007/7651_2016_345

Heterogeneity of stem cells : A brief overview. / Müzes, G.; Sípos, F.

Methods in Molecular Biology. Vol. 1516 Humana Press Inc., 2016. (Methods in Molecular Biology; Vol. 1516).

Research output: Chapter in Book/Report/Conference proceedingChapter

Müzes, G & Sípos, F 2016, Heterogeneity of stem cells: A brief overview. in Methods in Molecular Biology. vol. 1516, Methods in Molecular Biology, vol. 1516, Humana Press Inc. https://doi.org/10.1007/7651_2016_345
Müzes G, Sípos F. Heterogeneity of stem cells: A brief overview. In Methods in Molecular Biology. Vol. 1516. Humana Press Inc. 2016. (Methods in Molecular Biology). https://doi.org/10.1007/7651_2016_345
Müzes, G. ; Sípos, F. / Heterogeneity of stem cells : A brief overview. Methods in Molecular Biology. Vol. 1516 Humana Press Inc., 2016. (Methods in Molecular Biology).
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