Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis

Sebastian Mannweiler, Peter Amersdorfer, Slave Trajanoski, Jonathan A. Terrett, David King, G. Méhes

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is overexpressed in advanced stage prostate adenocarcinomas. As a novel target for in vivo prognostic and therapeutic approaches, the distribution pattern of PSMA in primary and metastatic tumors is of significant interest. In this study we addressed the cellular distribution and heterogeneity of PSMA expression. Paraffin-embedded sections of 51 patients with primary prostate carcinoma and distant metastases were evaluated. Immunohistochemistry was used to determine the cellular localization, staining intensity and positive cell fraction which were related to tumor type and growth pattern. We demonstrated differences in the intracellular localization of the PSMA immunostaining which seem to be related to the tumor differentiation pattern. A significant number of the primary tumors (7/51) and metastases (6/51) presented with highly heterogeneous PSMA expression and in further 2 primary, and 8 metastatic tumors the staining was in the negative range (

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalPathology and Oncology Research
Volume15
Issue number2
DOIs
Publication statusPublished - Jun 2009

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Prostate
Neoplasm Metastasis
Carcinoma
Neoplasms
Staining and Labeling
Paraffin
Adenocarcinoma
Immunohistochemistry
human glutamate carboxypeptidase II
Growth
Proteins
Therapeutics

Keywords

  • Antibody
  • Immunohistochemistry
  • Prostate cancer
  • Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. / Mannweiler, Sebastian; Amersdorfer, Peter; Trajanoski, Slave; Terrett, Jonathan A.; King, David; Méhes, G.

In: Pathology and Oncology Research, Vol. 15, No. 2, 06.2009, p. 167-172.

Research output: Contribution to journalArticle

Mannweiler, Sebastian ; Amersdorfer, Peter ; Trajanoski, Slave ; Terrett, Jonathan A. ; King, David ; Méhes, G. / Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. In: Pathology and Oncology Research. 2009 ; Vol. 15, No. 2. pp. 167-172.
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