Heterogeneity by cluster analysis techniques of Graves' patients typed for HLA DR and IgG heavy chain markers

M. F. Frecker, M. Preus, L. Kozma, E. Krasrits, V. Stenszky, C. Balázs, N. R. Farid

Research output: Contribution to journalArticle

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Abstract

In a previous study we were able to separate, using cluster analysis, 196 patients with Graves' disease evaluated for a large number of clinical and laboratory characteristics, including HLA-A and HLA-B typing into one subset with recurring disease and a high prevalence of ophthalmopathy and another subset with mild disease and little ophthalmopathy. Prevalence of HLA-B8 was much higher in the first as compared to the second group. The present study was undertaken in 117 new patients with Graves' disease, typed for HLA-A, HLA-B, HLA-C and DR antigens and IgG heavy chain markers, to determine whether these characteristics could be used to segregate patients into clinically relevant subsets. There was a greater proportion of Gm fb homozygotes among patients than am ong controls (χ2 = 4.71, p+ fb+ is 8.49, DR3+ fb- is 5.08, and DR3- fb+ is 1.42), this phenotype was distributed equally between the two clusters (48% in C1 and 58% in C2). We conclude that the use of HLA together with relatively few clinical characteristics results in the segregation of a severe and mild for of Graves' disease, and defines which individuals will respond to treatment with antithyroid drugs.

Original languageEnglish
Pages (from-to)63-71
Number of pages9
JournalMolecular Biology and Medicine
Volume3
Issue number1
Publication statusPublished - 1986

Fingerprint

HLA-DR alpha-Chains
Cluster Analysis
Graves Disease
Immunoglobulin G
HLA-A Antigens
HLA-B Antigens
HLA-B8 Antigen
HLA-C Antigens
Antithyroid Agents
Histocompatibility Testing
Homozygote
HLA-DR Antigens
Cerebral Palsy
Phenotype

ASJC Scopus subject areas

  • Genetics(clinical)
  • Molecular Biology

Cite this

Frecker, M. F., Preus, M., Kozma, L., Krasrits, E., Stenszky, V., Balázs, C., & Farid, N. R. (1986). Heterogeneity by cluster analysis techniques of Graves' patients typed for HLA DR and IgG heavy chain markers. Molecular Biology and Medicine, 3(1), 63-71.

Heterogeneity by cluster analysis techniques of Graves' patients typed for HLA DR and IgG heavy chain markers. / Frecker, M. F.; Preus, M.; Kozma, L.; Krasrits, E.; Stenszky, V.; Balázs, C.; Farid, N. R.

In: Molecular Biology and Medicine, Vol. 3, No. 1, 1986, p. 63-71.

Research output: Contribution to journalArticle

Frecker, MF, Preus, M, Kozma, L, Krasrits, E, Stenszky, V, Balázs, C & Farid, NR 1986, 'Heterogeneity by cluster analysis techniques of Graves' patients typed for HLA DR and IgG heavy chain markers', Molecular Biology and Medicine, vol. 3, no. 1, pp. 63-71.
Frecker, M. F. ; Preus, M. ; Kozma, L. ; Krasrits, E. ; Stenszky, V. ; Balázs, C. ; Farid, N. R. / Heterogeneity by cluster analysis techniques of Graves' patients typed for HLA DR and IgG heavy chain markers. In: Molecular Biology and Medicine. 1986 ; Vol. 3, No. 1. pp. 63-71.
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