Herpes virus antigens and antibodies in kidney biopsies and sera of IgA glomerulonephritic patients

J. Nagy, M. Uj, G. Szucs

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Antibody titers against 4 viruses of the herpes group have been studied in the sera of 54 patients with IgA glomerulonephritis (GN). The incidence of antibodies to herpes simplex virus type-1 (HSV-1), HSV-2, cytomegalovirus (CMV), Epstein-Barr virus nuclear antigen (EBNA), and that of IgG antibodies to EBV virus capsid antigen (VCA) were similar in patients and in controls. However, elevated antibody titers (≤ 64) to HSV and CMV occurred more frequently in patients with IgA GN than in healthy controls. Geometric mean titers to HSV and CMV were also higher in patients suffering from IgA GN than in controls. The incidence of IgA antibodies to EBV VCA occurred in patients with IgA GN significantly more often than in controls. There was a trace amount of HSV-2 antigen in 2 glomeruli of 1 renal biopsy. It is concluded that, in some patients with IgA GN, there is an abnormal immune response to certain types of herpes viruses.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalClinical Nephrology
Volume21
Issue number5
Publication statusPublished - Jan 1 1984

    Fingerprint

ASJC Scopus subject areas

  • Nephrology

Cite this