Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions

Gabor G. Kovacs, Monika Cs Horvath, K. Majtényi, Mirjam I. Lutz, Yasmin L. Hurd, E. Keller

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The observation of increased hyperphosphorylated tau levels correlating with microglial activation in opiate abusers has been interpreted as predisposition to accelerated Alzheimer disease-related changes. The present study focused on evaluating additional neurodegeneration-related proteins, including α-synuclein and TDP-43, and p62-positive deposits. We performed a systematic mapping of protein deposits in the brains of 27 individuals with documented heroin addiction (age: 19-40 years) and compared with 11 controls (age: 15-40 years). We confirm previous findings that heroin addiction associates with tau hyperphosphorylation in predilection brain areas for aging and Alzheimer disease. Furthermore, we show that this occurs also in areas implicated in the molecular disturbances and in vivo neuronal networks related to heroin abuse. There was, however, no presence of amyloid-beta deposits. We extend previous findings by showing the lack of TDP-43 or α-synuclein pathology and emphasize the independent effect of the duration of drug use on the appearance of age-related p62-positive neuritic profiles. These observations provide unique insights about neuropathological alterations in the brains of young heroin addicts and have implications about brain aging and the influences of environmental and toxic factors.

Original languageEnglish
Pages (from-to)3100-3107
Number of pages8
JournalNeurobiology of Aging
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Heroin Dependence
Synucleins
Brain
Opiate Alkaloids
Alzheimer Disease
Poisons
Heroin
Amyloid Plaques
Proteins
Observation
Pathology
Pharmaceutical Preparations

Keywords

  • Aging
  • Heroin
  • Neuropathology
  • Opiate
  • p62
  • Tau
  • TDP-43
  • α-Synuclein

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions. / Kovacs, Gabor G.; Horvath, Monika Cs; Majtényi, K.; Lutz, Mirjam I.; Hurd, Yasmin L.; Keller, E.

In: Neurobiology of Aging, Vol. 36, No. 11, 01.11.2015, p. 3100-3107.

Research output: Contribution to journalArticle

Kovacs, Gabor G. ; Horvath, Monika Cs ; Majtényi, K. ; Lutz, Mirjam I. ; Hurd, Yasmin L. ; Keller, E. / Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions. In: Neurobiology of Aging. 2015 ; Vol. 36, No. 11. pp. 3100-3107.
@article{caf5f99d160043ce8f5d194a3029fb59,
title = "Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions",
abstract = "The observation of increased hyperphosphorylated tau levels correlating with microglial activation in opiate abusers has been interpreted as predisposition to accelerated Alzheimer disease-related changes. The present study focused on evaluating additional neurodegeneration-related proteins, including α-synuclein and TDP-43, and p62-positive deposits. We performed a systematic mapping of protein deposits in the brains of 27 individuals with documented heroin addiction (age: 19-40 years) and compared with 11 controls (age: 15-40 years). We confirm previous findings that heroin addiction associates with tau hyperphosphorylation in predilection brain areas for aging and Alzheimer disease. Furthermore, we show that this occurs also in areas implicated in the molecular disturbances and in vivo neuronal networks related to heroin abuse. There was, however, no presence of amyloid-beta deposits. We extend previous findings by showing the lack of TDP-43 or α-synuclein pathology and emphasize the independent effect of the duration of drug use on the appearance of age-related p62-positive neuritic profiles. These observations provide unique insights about neuropathological alterations in the brains of young heroin addicts and have implications about brain aging and the influences of environmental and toxic factors.",
keywords = "Aging, Heroin, Neuropathology, Opiate, p62, Tau, TDP-43, α-Synuclein",
author = "Kovacs, {Gabor G.} and Horvath, {Monika Cs} and K. Majt{\'e}nyi and Lutz, {Mirjam I.} and Hurd, {Yasmin L.} and E. Keller",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.neurobiolaging.2015.07.018",
language = "English",
volume = "36",
pages = "3100--3107",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "11",

}

TY - JOUR

T1 - Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions

AU - Kovacs, Gabor G.

AU - Horvath, Monika Cs

AU - Majtényi, K.

AU - Lutz, Mirjam I.

AU - Hurd, Yasmin L.

AU - Keller, E.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - The observation of increased hyperphosphorylated tau levels correlating with microglial activation in opiate abusers has been interpreted as predisposition to accelerated Alzheimer disease-related changes. The present study focused on evaluating additional neurodegeneration-related proteins, including α-synuclein and TDP-43, and p62-positive deposits. We performed a systematic mapping of protein deposits in the brains of 27 individuals with documented heroin addiction (age: 19-40 years) and compared with 11 controls (age: 15-40 years). We confirm previous findings that heroin addiction associates with tau hyperphosphorylation in predilection brain areas for aging and Alzheimer disease. Furthermore, we show that this occurs also in areas implicated in the molecular disturbances and in vivo neuronal networks related to heroin abuse. There was, however, no presence of amyloid-beta deposits. We extend previous findings by showing the lack of TDP-43 or α-synuclein pathology and emphasize the independent effect of the duration of drug use on the appearance of age-related p62-positive neuritic profiles. These observations provide unique insights about neuropathological alterations in the brains of young heroin addicts and have implications about brain aging and the influences of environmental and toxic factors.

AB - The observation of increased hyperphosphorylated tau levels correlating with microglial activation in opiate abusers has been interpreted as predisposition to accelerated Alzheimer disease-related changes. The present study focused on evaluating additional neurodegeneration-related proteins, including α-synuclein and TDP-43, and p62-positive deposits. We performed a systematic mapping of protein deposits in the brains of 27 individuals with documented heroin addiction (age: 19-40 years) and compared with 11 controls (age: 15-40 years). We confirm previous findings that heroin addiction associates with tau hyperphosphorylation in predilection brain areas for aging and Alzheimer disease. Furthermore, we show that this occurs also in areas implicated in the molecular disturbances and in vivo neuronal networks related to heroin abuse. There was, however, no presence of amyloid-beta deposits. We extend previous findings by showing the lack of TDP-43 or α-synuclein pathology and emphasize the independent effect of the duration of drug use on the appearance of age-related p62-positive neuritic profiles. These observations provide unique insights about neuropathological alterations in the brains of young heroin addicts and have implications about brain aging and the influences of environmental and toxic factors.

KW - Aging

KW - Heroin

KW - Neuropathology

KW - Opiate

KW - p62

KW - Tau

KW - TDP-43

KW - α-Synuclein

UR - http://www.scopus.com/inward/record.url?scp=84947048054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947048054&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2015.07.018

DO - 10.1016/j.neurobiolaging.2015.07.018

M3 - Article

VL - 36

SP - 3100

EP - 3107

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 11

ER -