Heritability of venous biomechanics

Andrea Ágnes Molnár, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Zoltán Kulcsár, Levente Littvay, Zsolt Garami, I. Préda, R. Kiss, V. Bérczi, Ágnes Lannert, E. Monos, G. Nádasy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective-Altered venous biomechanics may contribute to the pathogenesis of venous diseases, and their heritability is less known. Methods and Results-Seventy-eight monozygotic twin pairs (aged 42.4±16.8 years) and 24 same-sex dizygotic twin pairs (aged 50.5±16.1 years) were examined. Anteroposterior and mediolateral diameters of the common femoral vein were measured by ultrasonography. Measurements were made both in supine and in standing body positions, with or without controlled forced expiration (Valsalva test). High correlation of diameter, capacity, and distensibility values was found between twin pairs. The univariate heritability (A), shared (C), and unshared (E) environmental effects model has shown 39.3% genetic component of the variance of low pressure, 37.9% of high-pressure venous capacity, and 36.4% of maximal capacity changes, even after elimination of sex, age, and body weight effects. Bivariate Cholesky analysis revealed substantial covariance of inherited body weight and venous capacity components (57.0%-81.4%). Conclusion-Femoral vein capacity and elasticity depend 30% to 40% on genetic factors, and this value in the standing body position can reach 50%. A relatively high genetic covariance was found between weight and femoral vein capacity and elasticity. Our work might yield some new insights into the inheritance of venous diseases that are associated with altered venous biomechanics and help elucidate the involved genes.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Femoral Vein
Biomechanical Phenomena
Elasticity
Body Weight
Dizygotic Twins
Venous Pressure
Monozygotic Twins
Ultrasonography
Pressure
Weights and Measures
Genes

Keywords

  • biomechanics
  • heritability
  • ultrasound
  • Valsalva
  • vein
  • venous

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Molnár, A. Á., Tárnoki, Á. D., Tárnoki, D. L., Kulcsár, Z., Littvay, L., Garami, Z., ... Nádasy, G. (2013). Heritability of venous biomechanics. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(1), 152-157. https://doi.org/10.1161/ATVBAHA.112.300062

Heritability of venous biomechanics. / Molnár, Andrea Ágnes; Tárnoki, Ádám Domonkos; Tárnoki, Dávid László; Kulcsár, Zoltán; Littvay, Levente; Garami, Zsolt; Préda, I.; Kiss, R.; Bérczi, V.; Lannert, Ágnes; Monos, E.; Nádasy, G.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 33, No. 1, 01.2013, p. 152-157.

Research output: Contribution to journalArticle

Molnár, AÁ, Tárnoki, ÁD, Tárnoki, DL, Kulcsár, Z, Littvay, L, Garami, Z, Préda, I, Kiss, R, Bérczi, V, Lannert, Á, Monos, E & Nádasy, G 2013, 'Heritability of venous biomechanics', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 33, no. 1, pp. 152-157. https://doi.org/10.1161/ATVBAHA.112.300062
Molnár AÁ, Tárnoki ÁD, Tárnoki DL, Kulcsár Z, Littvay L, Garami Z et al. Heritability of venous biomechanics. Arteriosclerosis, Thrombosis, and Vascular Biology. 2013 Jan;33(1):152-157. https://doi.org/10.1161/ATVBAHA.112.300062
Molnár, Andrea Ágnes ; Tárnoki, Ádám Domonkos ; Tárnoki, Dávid László ; Kulcsár, Zoltán ; Littvay, Levente ; Garami, Zsolt ; Préda, I. ; Kiss, R. ; Bérczi, V. ; Lannert, Ágnes ; Monos, E. ; Nádasy, G. / Heritability of venous biomechanics. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2013 ; Vol. 33, No. 1. pp. 152-157.
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abstract = "Objective-Altered venous biomechanics may contribute to the pathogenesis of venous diseases, and their heritability is less known. Methods and Results-Seventy-eight monozygotic twin pairs (aged 42.4±16.8 years) and 24 same-sex dizygotic twin pairs (aged 50.5±16.1 years) were examined. Anteroposterior and mediolateral diameters of the common femoral vein were measured by ultrasonography. Measurements were made both in supine and in standing body positions, with or without controlled forced expiration (Valsalva test). High correlation of diameter, capacity, and distensibility values was found between twin pairs. The univariate heritability (A), shared (C), and unshared (E) environmental effects model has shown 39.3{\%} genetic component of the variance of low pressure, 37.9{\%} of high-pressure venous capacity, and 36.4{\%} of maximal capacity changes, even after elimination of sex, age, and body weight effects. Bivariate Cholesky analysis revealed substantial covariance of inherited body weight and venous capacity components (57.0{\%}-81.4{\%}). Conclusion-Femoral vein capacity and elasticity depend 30{\%} to 40{\%} on genetic factors, and this value in the standing body position can reach 50{\%}. A relatively high genetic covariance was found between weight and femoral vein capacity and elasticity. Our work might yield some new insights into the inheritance of venous diseases that are associated with altered venous biomechanics and help elucidate the involved genes.",
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AU - Littvay, Levente

AU - Garami, Zsolt

AU - Préda, I.

AU - Kiss, R.

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