Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters

A twin study

Adam D. Tarnoki, David L. Tarnoki, Pal Bata, Levente Littvay, J. Osztovits, G. Jermendy, K. Karlinger, Agnes Lannert, I. Préda, R. Kiss, Andrea A. Molnar, Zsolt Garami, Gyorgy Baffy, V. Bérczi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) has been linked to increased cardiovascular morbidity. However, genetic factors have an unclear role in this condition. Aims: To analyse heritability of NAFLD and its association with abnormal vascular parameters in a large twin cohort. Methods: Anthropometric and lipid metabolic parameters were obtained from 208 adult Hungarian twins (63 monozygotic and 41 dizygotic pairs; 58 men and 150 women; age 43.7 ± 16.7 years). B-mode ultrasonography was performed to detect steatosis and categorize severity. Brachial and aortic augmentation indices and aortic pulse wave velocity were assessed using oscillometry (TensioMed Arteriograph). Carotid intima media thickness (IMT) was measured using ultrasonography on the proximal common, distal common and internal carotid arteries. Results: NAFLD was identified in 47 subjects (22.6%), of which 44 (93.6%) had mild and 3 (6.4%) had moderate steatosis. These subjects were older (age: 50.9 ± 14.3 vs. 41.5 ± 16.7 years, P <0.001) and had a higher body mass index (BMI; 30.1 ± 5.2 vs. 24.6 ± 4.1 km/m2, P <0.001) than non-NAFLD twins. Based on 91 same-sex twin pairs, heritability analysis indicated no discernible role for genetic components in the presence of NAFLD (95% confidence interval, 0.0-36.0%), while shared and unshared environmental effects accounted for 74.2% and 25.8% of variations adjusted for age and BMI. Augmentation indices and carotid IMT in twins with NAFLD were increased at most examined locations (P <0.05-P <0.001). Conclusion: These findings do not support heritability of NAFLD, although it coexists with vascular parameters linked to increased cardiovascular risk, underscoring the importance and value of prevention in this very common disorder.

Original languageEnglish
Pages (from-to)1287-1293
Number of pages7
JournalLiver International
Volume32
Issue number8
DOIs
Publication statusPublished - Sep 2012

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Twin Studies
Blood Vessels
Carotid Intima-Media Thickness
Ultrasonography
Oscillometry
Pulse Wave Analysis
Monozygotic Twins
Common Carotid Artery
Internal Carotid Artery
Fatty Liver
Non-alcoholic Fatty Liver Disease
Liver Diseases
Body Mass Index
Arm
Confidence Intervals
Morbidity
Lipids

Keywords

  • Arterial stiffness
  • Genetics
  • Heritability
  • Intima media thickness
  • Steatosis

ASJC Scopus subject areas

  • Hepatology

Cite this

Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters : A twin study. / Tarnoki, Adam D.; Tarnoki, David L.; Bata, Pal; Littvay, Levente; Osztovits, J.; Jermendy, G.; Karlinger, K.; Lannert, Agnes; Préda, I.; Kiss, R.; Molnar, Andrea A.; Garami, Zsolt; Baffy, Gyorgy; Bérczi, V.

In: Liver International, Vol. 32, No. 8, 09.2012, p. 1287-1293.

Research output: Contribution to journalArticle

Tarnoki, Adam D. ; Tarnoki, David L. ; Bata, Pal ; Littvay, Levente ; Osztovits, J. ; Jermendy, G. ; Karlinger, K. ; Lannert, Agnes ; Préda, I. ; Kiss, R. ; Molnar, Andrea A. ; Garami, Zsolt ; Baffy, Gyorgy ; Bérczi, V. / Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters : A twin study. In: Liver International. 2012 ; Vol. 32, No. 8. pp. 1287-1293.
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abstract = "Background: Non-alcoholic fatty liver disease (NAFLD) has been linked to increased cardiovascular morbidity. However, genetic factors have an unclear role in this condition. Aims: To analyse heritability of NAFLD and its association with abnormal vascular parameters in a large twin cohort. Methods: Anthropometric and lipid metabolic parameters were obtained from 208 adult Hungarian twins (63 monozygotic and 41 dizygotic pairs; 58 men and 150 women; age 43.7 ± 16.7 years). B-mode ultrasonography was performed to detect steatosis and categorize severity. Brachial and aortic augmentation indices and aortic pulse wave velocity were assessed using oscillometry (TensioMed Arteriograph). Carotid intima media thickness (IMT) was measured using ultrasonography on the proximal common, distal common and internal carotid arteries. Results: NAFLD was identified in 47 subjects (22.6{\%}), of which 44 (93.6{\%}) had mild and 3 (6.4{\%}) had moderate steatosis. These subjects were older (age: 50.9 ± 14.3 vs. 41.5 ± 16.7 years, P <0.001) and had a higher body mass index (BMI; 30.1 ± 5.2 vs. 24.6 ± 4.1 km/m2, P <0.001) than non-NAFLD twins. Based on 91 same-sex twin pairs, heritability analysis indicated no discernible role for genetic components in the presence of NAFLD (95{\%} confidence interval, 0.0-36.0{\%}), while shared and unshared environmental effects accounted for 74.2{\%} and 25.8{\%} of variations adjusted for age and BMI. Augmentation indices and carotid IMT in twins with NAFLD were increased at most examined locations (P <0.05-P <0.001). Conclusion: These findings do not support heritability of NAFLD, although it coexists with vascular parameters linked to increased cardiovascular risk, underscoring the importance and value of prevention in this very common disorder.",
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AU - Littvay, Levente

AU - Osztovits, J.

AU - Jermendy, G.

AU - Karlinger, K.

AU - Lannert, Agnes

AU - Préda, I.

AU - Kiss, R.

AU - Molnar, Andrea A.

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N2 - Background: Non-alcoholic fatty liver disease (NAFLD) has been linked to increased cardiovascular morbidity. However, genetic factors have an unclear role in this condition. Aims: To analyse heritability of NAFLD and its association with abnormal vascular parameters in a large twin cohort. Methods: Anthropometric and lipid metabolic parameters were obtained from 208 adult Hungarian twins (63 monozygotic and 41 dizygotic pairs; 58 men and 150 women; age 43.7 ± 16.7 years). B-mode ultrasonography was performed to detect steatosis and categorize severity. Brachial and aortic augmentation indices and aortic pulse wave velocity were assessed using oscillometry (TensioMed Arteriograph). Carotid intima media thickness (IMT) was measured using ultrasonography on the proximal common, distal common and internal carotid arteries. Results: NAFLD was identified in 47 subjects (22.6%), of which 44 (93.6%) had mild and 3 (6.4%) had moderate steatosis. These subjects were older (age: 50.9 ± 14.3 vs. 41.5 ± 16.7 years, P <0.001) and had a higher body mass index (BMI; 30.1 ± 5.2 vs. 24.6 ± 4.1 km/m2, P <0.001) than non-NAFLD twins. Based on 91 same-sex twin pairs, heritability analysis indicated no discernible role for genetic components in the presence of NAFLD (95% confidence interval, 0.0-36.0%), while shared and unshared environmental effects accounted for 74.2% and 25.8% of variations adjusted for age and BMI. Augmentation indices and carotid IMT in twins with NAFLD were increased at most examined locations (P <0.05-P <0.001). Conclusion: These findings do not support heritability of NAFLD, although it coexists with vascular parameters linked to increased cardiovascular risk, underscoring the importance and value of prevention in this very common disorder.

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