Hereditary diabetes insipidus in rats: Altered cerebral indolamine and catecholamine metabolism

G. Kovács, G. Szabó, L. Szontágh, L. Medve, G. Telegdy, F. László

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Compared to heterozygous Brattleboro animals, homozygous (diabetes insipidus) rats exhibited higher steady-state levels of serotonin in the mesencephalon, septum and striatum. These differences disappeared upon the administration of pargyline, suggesting a decreased accumulation of serotonin. The norepinephrine level was higher in the mesencephalon, while the disappearance rate (α-methyl-p-tyrosine) was accelerated in the septum and decreased in the hypothalamus. The lower striatal dopamine level was associated with a decreased disappearance rate. The data suggest that the altered monoamine metabolism might be associated with the known endocrine and behavioral disturbances of the homozygous rats.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalNeuroendocrinology
Volume31
Issue number3
DOIs
Publication statusPublished - 1980

Fingerprint

Diabetes Insipidus
Mesencephalon
Catecholamines
Serotonin
Pargyline
Corpus Striatum
Hypothalamus
Tyrosine
Dopamine
Norepinephrine
indolamine

Keywords

  • Diabetes insipidus
  • Dopamine
  • Noradrenaline
  • Serotonin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Hereditary diabetes insipidus in rats : Altered cerebral indolamine and catecholamine metabolism. / Kovács, G.; Szabó, G.; Szontágh, L.; Medve, L.; Telegdy, G.; László, F.

In: Neuroendocrinology, Vol. 31, No. 3, 1980, p. 189-193.

Research output: Contribution to journalArticle

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