Hereditary catalase deficiencies and increased risk of diabetes

László Góth, John W. Eaton

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Abstract

Partial or near-total lack of erythrocyte catalase activity is a rare condition, generally thought to be benign. However, little is known of the frequency of common diseases of adult onset in human beings with catalase deficiency. We report that, in a series of Hungarian patients with catalase deficiency, there is a higher frequency of diabetes than in unaffected first-degree relatives and the general Hungarian population. We speculate that quantitative deficiency of catalase might predispose to cumulative oxidant damage of pancreatic β-cells and diabetes.

Original languageEnglish
Pages (from-to)1820-1821
Number of pages2
JournalLancet
Volume356
Issue number9244
DOIs
Publication statusPublished - Nov 25 2000

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ASJC Scopus subject areas

  • Medicine(all)

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