Hereditary angiodema

A current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema

Tom Bowen, Marco Cicardi, Konrad Bork, Bruce Zuraw, Mike Frank, Bruce Ritchie, H. Farkas, L. Varga, Lorenza C. Zingale, Karen Binkley, Eric Wagner, Peggy Adomaitis, Kristylea Brosz, Jeanne Burnham, Richard Warrington, Chrystyna Kalicinsky, Sean Mace, Christine McCusker, Robert Schellenberg, Lucia Celeste & 38 others Jacques Hebert, Karen Valentine, Man Chiu Poon, Bazir Serushago, Doris Neurath, William Yang, Gina Lacuesta, Andrew Issekutz, Azza Hamed, Palinder Kamra, John Dean, Amin Kanani, Donald Stark, Georges Etienne Rivard, Eric Leith, Ellie Tsai, Susan Waserman, Paul K. Keith, David Page, Silvia Marchesin, Hilary J. Longhurst, Wolfhart Kreuz, Eva Rusicke, Inmaculada Martinez-Saguer, Emel Aygören-Pürsün, G. Harmat, G. Füst, Henry Li, Laurence Bouillet, Teresa Caballero, Dumitru Moldovan, Peter J. Späth, Sara Smith-Foltz, Istvan Nagy, Erik W. Nielsen, Christoph Bucher, Patrik Nordenfeit, Yu Xiang Zhi

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Background: We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) in 2004. Objective: To ensure that this consensus remains current. Methods: In collaboration with the Canadian Network of Rare Blood Disorder Organizations, we held the second Canadian Consensus discussion with our international colleagues in Toronto, Ontario, on February 3, 2006, and reviewed its content at the Fifth C1 Inhibitor Deficiency Workshop in Budapest on June 2, 2007. Papers were presented by international investigators, and this consensus algorithm approach resulted. Results: This consensus algorithm outlines the approach recommended for the diagnosis, therapy, and management of HAE, which was agreed on by the authors of this report. This document is only a consensus algorithm approach and continues to require validation. As such, participants agreed to make this a living 2007 algorithm, a work in progress, and to review its content at future international HAE meetings. Conclusions: There is a paucity of double-blind, placebo-controlled trials on the treatment of HAE, making levels of evidence to support the algorithm less than optimal. Controlled trials currently under way will provide further insight into the management of HAE. As with our Canadian 2003 Consensus, this 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of HAE was formed through the meeting and agreement of patient care professionals along with patient group representatives and individual patients.

Original languageEnglish
JournalAnnals of Allergy, Asthma and Immunology
Volume100
Issue number1 SUPPL. 2
Publication statusPublished - Jan 2008

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Hereditary Angioedemas
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  • Immunology and Allergy

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Hereditary angiodema : A current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. / Bowen, Tom; Cicardi, Marco; Bork, Konrad; Zuraw, Bruce; Frank, Mike; Ritchie, Bruce; Farkas, H.; Varga, L.; Zingale, Lorenza C.; Binkley, Karen; Wagner, Eric; Adomaitis, Peggy; Brosz, Kristylea; Burnham, Jeanne; Warrington, Richard; Kalicinsky, Chrystyna; Mace, Sean; McCusker, Christine; Schellenberg, Robert; Celeste, Lucia; Hebert, Jacques; Valentine, Karen; Poon, Man Chiu; Serushago, Bazir; Neurath, Doris; Yang, William; Lacuesta, Gina; Issekutz, Andrew; Hamed, Azza; Kamra, Palinder; Dean, John; Kanani, Amin; Stark, Donald; Rivard, Georges Etienne; Leith, Eric; Tsai, Ellie; Waserman, Susan; Keith, Paul K.; Page, David; Marchesin, Silvia; Longhurst, Hilary J.; Kreuz, Wolfhart; Rusicke, Eva; Martinez-Saguer, Inmaculada; Aygören-Pürsün, Emel; Harmat, G.; Füst, G.; Li, Henry; Bouillet, Laurence; Caballero, Teresa; Moldovan, Dumitru; Späth, Peter J.; Smith-Foltz, Sara; Nagy, Istvan; Nielsen, Erik W.; Bucher, Christoph; Nordenfeit, Patrik; Zhi, Yu Xiang.

In: Annals of Allergy, Asthma and Immunology, Vol. 100, No. 1 SUPPL. 2, 01.2008.

Research output: Contribution to journalArticle

Bowen, T, Cicardi, M, Bork, K, Zuraw, B, Frank, M, Ritchie, B, Farkas, H, Varga, L, Zingale, LC, Binkley, K, Wagner, E, Adomaitis, P, Brosz, K, Burnham, J, Warrington, R, Kalicinsky, C, Mace, S, McCusker, C, Schellenberg, R, Celeste, L, Hebert, J, Valentine, K, Poon, MC, Serushago, B, Neurath, D, Yang, W, Lacuesta, G, Issekutz, A, Hamed, A, Kamra, P, Dean, J, Kanani, A, Stark, D, Rivard, GE, Leith, E, Tsai, E, Waserman, S, Keith, PK, Page, D, Marchesin, S, Longhurst, HJ, Kreuz, W, Rusicke, E, Martinez-Saguer, I, Aygören-Pürsün, E, Harmat, G, Füst, G, Li, H, Bouillet, L, Caballero, T, Moldovan, D, Späth, PJ, Smith-Foltz, S, Nagy, I, Nielsen, EW, Bucher, C, Nordenfeit, P & Zhi, YX 2008, 'Hereditary angiodema: A current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema', Annals of Allergy, Asthma and Immunology, vol. 100, no. 1 SUPPL. 2.
Bowen, Tom ; Cicardi, Marco ; Bork, Konrad ; Zuraw, Bruce ; Frank, Mike ; Ritchie, Bruce ; Farkas, H. ; Varga, L. ; Zingale, Lorenza C. ; Binkley, Karen ; Wagner, Eric ; Adomaitis, Peggy ; Brosz, Kristylea ; Burnham, Jeanne ; Warrington, Richard ; Kalicinsky, Chrystyna ; Mace, Sean ; McCusker, Christine ; Schellenberg, Robert ; Celeste, Lucia ; Hebert, Jacques ; Valentine, Karen ; Poon, Man Chiu ; Serushago, Bazir ; Neurath, Doris ; Yang, William ; Lacuesta, Gina ; Issekutz, Andrew ; Hamed, Azza ; Kamra, Palinder ; Dean, John ; Kanani, Amin ; Stark, Donald ; Rivard, Georges Etienne ; Leith, Eric ; Tsai, Ellie ; Waserman, Susan ; Keith, Paul K. ; Page, David ; Marchesin, Silvia ; Longhurst, Hilary J. ; Kreuz, Wolfhart ; Rusicke, Eva ; Martinez-Saguer, Inmaculada ; Aygören-Pürsün, Emel ; Harmat, G. ; Füst, G. ; Li, Henry ; Bouillet, Laurence ; Caballero, Teresa ; Moldovan, Dumitru ; Späth, Peter J. ; Smith-Foltz, Sara ; Nagy, Istvan ; Nielsen, Erik W. ; Bucher, Christoph ; Nordenfeit, Patrik ; Zhi, Yu Xiang. / Hereditary angiodema : A current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. In: Annals of Allergy, Asthma and Immunology. 2008 ; Vol. 100, No. 1 SUPPL. 2.
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title = "Hereditary angiodema: A current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema",
abstract = "Background: We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) in 2004. Objective: To ensure that this consensus remains current. Methods: In collaboration with the Canadian Network of Rare Blood Disorder Organizations, we held the second Canadian Consensus discussion with our international colleagues in Toronto, Ontario, on February 3, 2006, and reviewed its content at the Fifth C1 Inhibitor Deficiency Workshop in Budapest on June 2, 2007. Papers were presented by international investigators, and this consensus algorithm approach resulted. Results: This consensus algorithm outlines the approach recommended for the diagnosis, therapy, and management of HAE, which was agreed on by the authors of this report. This document is only a consensus algorithm approach and continues to require validation. As such, participants agreed to make this a living 2007 algorithm, a work in progress, and to review its content at future international HAE meetings. Conclusions: There is a paucity of double-blind, placebo-controlled trials on the treatment of HAE, making levels of evidence to support the algorithm less than optimal. Controlled trials currently under way will provide further insight into the management of HAE. As with our Canadian 2003 Consensus, this 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of HAE was formed through the meeting and agreement of patient care professionals along with patient group representatives and individual patients.",
author = "Tom Bowen and Marco Cicardi and Konrad Bork and Bruce Zuraw and Mike Frank and Bruce Ritchie and H. Farkas and L. Varga and Zingale, {Lorenza C.} and Karen Binkley and Eric Wagner and Peggy Adomaitis and Kristylea Brosz and Jeanne Burnham and Richard Warrington and Chrystyna Kalicinsky and Sean Mace and Christine McCusker and Robert Schellenberg and Lucia Celeste and Jacques Hebert and Karen Valentine and Poon, {Man Chiu} and Bazir Serushago and Doris Neurath and William Yang and Gina Lacuesta and Andrew Issekutz and Azza Hamed and Palinder Kamra and John Dean and Amin Kanani and Donald Stark and Rivard, {Georges Etienne} and Eric Leith and Ellie Tsai and Susan Waserman and Keith, {Paul K.} and David Page and Silvia Marchesin and Longhurst, {Hilary J.} and Wolfhart Kreuz and Eva Rusicke and Inmaculada Martinez-Saguer and Emel Ayg{\"o}ren-P{\"u}rs{\"u}n and G. Harmat and G. F{\"u}st and Henry Li and Laurence Bouillet and Teresa Caballero and Dumitru Moldovan and Sp{\"a}th, {Peter J.} and Sara Smith-Foltz and Istvan Nagy and Nielsen, {Erik W.} and Christoph Bucher and Patrik Nordenfeit and Zhi, {Yu Xiang}",
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T1 - Hereditary angiodema

T2 - A current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema

AU - Bowen, Tom

AU - Cicardi, Marco

AU - Bork, Konrad

AU - Zuraw, Bruce

AU - Frank, Mike

AU - Ritchie, Bruce

AU - Farkas, H.

AU - Varga, L.

AU - Zingale, Lorenza C.

AU - Binkley, Karen

AU - Wagner, Eric

AU - Adomaitis, Peggy

AU - Brosz, Kristylea

AU - Burnham, Jeanne

AU - Warrington, Richard

AU - Kalicinsky, Chrystyna

AU - Mace, Sean

AU - McCusker, Christine

AU - Schellenberg, Robert

AU - Celeste, Lucia

AU - Hebert, Jacques

AU - Valentine, Karen

AU - Poon, Man Chiu

AU - Serushago, Bazir

AU - Neurath, Doris

AU - Yang, William

AU - Lacuesta, Gina

AU - Issekutz, Andrew

AU - Hamed, Azza

AU - Kamra, Palinder

AU - Dean, John

AU - Kanani, Amin

AU - Stark, Donald

AU - Rivard, Georges Etienne

AU - Leith, Eric

AU - Tsai, Ellie

AU - Waserman, Susan

AU - Keith, Paul K.

AU - Page, David

AU - Marchesin, Silvia

AU - Longhurst, Hilary J.

AU - Kreuz, Wolfhart

AU - Rusicke, Eva

AU - Martinez-Saguer, Inmaculada

AU - Aygören-Pürsün, Emel

AU - Harmat, G.

AU - Füst, G.

AU - Li, Henry

AU - Bouillet, Laurence

AU - Caballero, Teresa

AU - Moldovan, Dumitru

AU - Späth, Peter J.

AU - Smith-Foltz, Sara

AU - Nagy, Istvan

AU - Nielsen, Erik W.

AU - Bucher, Christoph

AU - Nordenfeit, Patrik

AU - Zhi, Yu Xiang

PY - 2008/1

Y1 - 2008/1

N2 - Background: We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) in 2004. Objective: To ensure that this consensus remains current. Methods: In collaboration with the Canadian Network of Rare Blood Disorder Organizations, we held the second Canadian Consensus discussion with our international colleagues in Toronto, Ontario, on February 3, 2006, and reviewed its content at the Fifth C1 Inhibitor Deficiency Workshop in Budapest on June 2, 2007. Papers were presented by international investigators, and this consensus algorithm approach resulted. Results: This consensus algorithm outlines the approach recommended for the diagnosis, therapy, and management of HAE, which was agreed on by the authors of this report. This document is only a consensus algorithm approach and continues to require validation. As such, participants agreed to make this a living 2007 algorithm, a work in progress, and to review its content at future international HAE meetings. Conclusions: There is a paucity of double-blind, placebo-controlled trials on the treatment of HAE, making levels of evidence to support the algorithm less than optimal. Controlled trials currently under way will provide further insight into the management of HAE. As with our Canadian 2003 Consensus, this 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of HAE was formed through the meeting and agreement of patient care professionals along with patient group representatives and individual patients.

AB - Background: We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) in 2004. Objective: To ensure that this consensus remains current. Methods: In collaboration with the Canadian Network of Rare Blood Disorder Organizations, we held the second Canadian Consensus discussion with our international colleagues in Toronto, Ontario, on February 3, 2006, and reviewed its content at the Fifth C1 Inhibitor Deficiency Workshop in Budapest on June 2, 2007. Papers were presented by international investigators, and this consensus algorithm approach resulted. Results: This consensus algorithm outlines the approach recommended for the diagnosis, therapy, and management of HAE, which was agreed on by the authors of this report. This document is only a consensus algorithm approach and continues to require validation. As such, participants agreed to make this a living 2007 algorithm, a work in progress, and to review its content at future international HAE meetings. Conclusions: There is a paucity of double-blind, placebo-controlled trials on the treatment of HAE, making levels of evidence to support the algorithm less than optimal. Controlled trials currently under way will provide further insight into the management of HAE. As with our Canadian 2003 Consensus, this 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of HAE was formed through the meeting and agreement of patient care professionals along with patient group representatives and individual patients.

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VL - 100

JO - Annals of Allergy, Asthma and Immunology

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