Hepcidin concentrations and iron homeostasis in preeclampsia

Gergely Toldi, Balázs Stenczer, A. Molvarec, Zoltán Takáts, G. Bekő, J. Rigó, B. Vásárhelyi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Plasma iron is increased in preeclampsia (PE) when compared to healthy pregnant women. This is in contrast to inflammation characteristic for PE. The link between iron homeostasis and inflammation is hepcidin. Our goal was to describe hepcidin concentrations and its association with iron homeostasis in PE. Methods: We obtained peripheral blood samples from 30 preeclamptic [gestational age: 36.5 (24-40) weeks] and 37 healthy pregnant women [gestational age: 36 (28-39) weeks] to determine plasma hepcidin and interleukin-6 (IL-6) concentrations, complete blood cell counts and parameters of iron homeostasis [plasma iron, transferrin and ferritin levels and total iron binding capacity (TIBC)]. Hepcidin was measured using mass spectrophotometry. The Mann-Whitney test was used for statistical analysis. Results: Plasma hepcidin, IL-6, iron and ferritin concentrations were increased (p

Original languageEnglish
Pages (from-to)1423-1426
Number of pages4
JournalClinical Chemistry and Laboratory Medicine
Volume48
Issue number10
DOIs
Publication statusPublished - Oct 1 2010

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Hepcidins
Pre-Eclampsia
Homeostasis
Iron
Plasmas
Blood Cell Count
Ferritins
Gestational Age
Pregnant Women
Interleukin-6
Blood
Inflammation
Spectrophotometry
Transferrin
Statistical methods
Cells

Keywords

  • hepcidin
  • interleukin-6
  • iron homeostasis
  • preeclampsia

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Hepcidin concentrations and iron homeostasis in preeclampsia. / Toldi, Gergely; Stenczer, Balázs; Molvarec, A.; Takáts, Zoltán; Bekő, G.; Rigó, J.; Vásárhelyi, B.

In: Clinical Chemistry and Laboratory Medicine, Vol. 48, No. 10, 01.10.2010, p. 1423-1426.

Research output: Contribution to journalArticle

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AU - Rigó, J.

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