Hepcidin and its potential clinical utility

Attila Miseta, Judit Nagy, Tamas Nagy, Viktor Soma Poór, Zsuzsanna Fekete, Katalin Sipos

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

A number of pathophysiological conditions are related to iron metabolism disturbances. Some of them are well known, others are newly discovered or special. Hepcidin is a newly identified iron metabolism regulating hormone, which could be a promising biomarker for many disorders. In this review, we provide background information about mammalian iron metabolism, cellular iron trafficking, and the regulation of expression of hepcidin. Beside these molecular biological processes, we summarize the methods that have been used to determine blood and urine hepcidin levels and present those pathological conditions (cancer, inflammation, neurological disorders) when hepcidin measurement may have clinical relevance.

Original languageEnglish
Pages (from-to)1191-1202
Number of pages12
JournalCell biology international
Volume39
Issue number11
DOIs
Publication statusPublished - Nov 2015

Keywords

  • Diagnostics
  • Hepcidin
  • Iron homeostasis
  • Liver
  • Prohepcidin

ASJC Scopus subject areas

  • Cell Biology

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