Hepatosplenic γδ T-cell lymphoma with leukemic phase successfully treated with 2-chlorodeoxyadenosine

László Gopcsa, Anikó Bányai, Júlia Tamáska, Ágnes Karádi, András Matolcsy, Katalin Pálóczi

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9 Citations (Scopus)


An unusual case of hepatosplenic γδ T-cell lymphoma with leukemic phase in a 39-year-old woman is reported. At the first presentation she had splenomegaly and pancytopenia diagnosed as hypersplenia treated by splenectomy. Subsequently, she developed hepatomegaly and progressive neoplastic lymphocytosis. The bone marrow showed a sinusoidal infiltrate of medium-sized cells. Flowcytometric analysis of peripheral blood mononuclear cells demonstrated expression of CD3, CD7, CD16, CD56 antigens and T-cell receptor γδ. A monoclonal TCRγ- and β-chain gene rearrangement were detected by polymerase chain reaction. The patient was treated by traditional chemotherapy and α-interferon, unsuccessfully. Therefore, 2-chlorodeoxyadenosine was introduced resulting in a complete remission for 6 months. The reported case demonstrates the usefulness of 2-chlorodeoxyadenosine in treatment of hepatosplenic γδ T-cell lymphoma.

Original languageEnglish
Pages (from-to)519-527
Number of pages9
Issue number4
Publication statusPublished - Dec 1 2002



  • 2-Chlorodeoxyadenosine
  • Extranodal T/NK-cell lymphoma
  • Hepatosplenic γδ T-cell lymphoma
  • Purine analogues

ASJC Scopus subject areas

  • Hematology

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