Hepatosplenic γδ T-cell lymphoma with leukemic phase successfully treated with 2-chlorodeoxyadenosine

László Gopcsa, Anikó Bányai, Júlia Tamáska, Ágnes Karádi, A. Matolcsy, K. Pálóczi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An unusual case of hepatosplenic γδ T-cell lymphoma with leukemic phase in a 39-year-old woman is reported. At the first presentation she had splenomegaly and pancytopenia diagnosed as hypersplenia treated by splenectomy. Subsequently, she developed hepatomegaly and progressive neoplastic lymphocytosis. The bone marrow showed a sinusoidal infiltrate of medium-sized cells. Flowcytometric analysis of peripheral blood mononuclear cells demonstrated expression of CD3, CD7, CD16, CD56 antigens and T-cell receptor γδ. A monoclonal TCRγ- and β-chain gene rearrangement were detected by polymerase chain reaction. The patient was treated by traditional chemotherapy and α-interferon, unsuccessfully. Therefore, 2-chlorodeoxyadenosine was introduced resulting in a complete remission for 6 months. The reported case demonstrates the usefulness of 2-chlorodeoxyadenosine in treatment of hepatosplenic γδ T-cell lymphoma.

Original languageEnglish
Pages (from-to)519-527
Number of pages9
JournalHaematologia
Volume32
Issue number4
Publication statusPublished - 2002

Fingerprint

Cladribine
T-Cell Lymphoma
CD56 Antigens
Hypersplenism
IgG Receptors
Lymphocytosis
Pancytopenia
Hepatomegaly
Gene Rearrangement
Splenomegaly
Splenectomy
T-Cell Antigen Receptor
Interferons
Blood Cells
Bone Marrow
Drug Therapy
Polymerase Chain Reaction
Therapeutics

Keywords

  • 2-Chlorodeoxyadenosine
  • Extranodal T/NK-cell lymphoma
  • Hepatosplenic γδ T-cell lymphoma
  • Purine analogues

ASJC Scopus subject areas

  • Hematology

Cite this

Hepatosplenic γδ T-cell lymphoma with leukemic phase successfully treated with 2-chlorodeoxyadenosine. / Gopcsa, László; Bányai, Anikó; Tamáska, Júlia; Karádi, Ágnes; Matolcsy, A.; Pálóczi, K.

In: Haematologia, Vol. 32, No. 4, 2002, p. 519-527.

Research output: Contribution to journalArticle

Gopcsa, László ; Bányai, Anikó ; Tamáska, Júlia ; Karádi, Ágnes ; Matolcsy, A. ; Pálóczi, K. / Hepatosplenic γδ T-cell lymphoma with leukemic phase successfully treated with 2-chlorodeoxyadenosine. In: Haematologia. 2002 ; Vol. 32, No. 4. pp. 519-527.
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