Hepatoprotective liposomal glycyrrhizin in alcoholic liver injury

Dénes Kleiner, Gabriella Hegyi, Rudolf Urbanics, László Dézsi, Hermina Robotka, E. Fehér, Éva Sárdi, János Szebeni, Anna Blázovics

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction Licorice root (Glycyrrhiza glabra L.) extract and its main active component glycyrrhizin, as well as derivates are well known hepatoprotective and gastroprotective agents. Liposomal applications of these compounds may prevent low bioavailability and side-effects, e.g. pseudoaldosteronism and has further benefits, because the nanoparticles with glycyrrhizin and glycyrrhetinic acid have enhanced uptake into the liver. Our aim was to study the hepatoprotective effect of liposomal glycyrrhizin treatment during long-term alcohol consumption in rats. Methods Harlan-Wistar (175–200 g) rats were randomly allocated into three groups: control, alcoholic, ethanol and liposomal glycyrrhizin-treated. The redox status of the liver was studied with the measurement of free sulfhydryl-group concentration and hydrogen-donor ability. Transmethylation capacity was measured in dimedone adduct form. Histological examination was carried out as well. Results Data showed mild elevation in the hydrogen-donor ability and slightly lowered free sulfhydryl level, although transmethylation capacity was significantly lowered (p < 0,05) in the alcoholic group. Liposomal glycyrrhizin caused no marked histological changes. Effect of the treatment on the redox homeostasis and transmethylation capacity was beneficial. Conclusions Liposomal glycyrrhizin treatment moderated the alcohol-related negative changes, therefore glycyrrhizin and/or its derivatives may have further impact in the treatment of alcoholic liver diseases.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalEuropean Journal of Integrative Medicine
Volume8
DOIs
Publication statusPublished - Sep 1 2016

Fingerprint

Glycyrrhizic Acid
Liver
Wounds and Injuries
Glycyrrhiza
Aptitude
Oxidation-Reduction
Hydrogen
Liddle Syndrome
Glycyrrhetinic Acid
Alcoholic Liver Diseases
Therapeutics
Alcohol Drinking
Nanoparticles
Biological Availability
Homeostasis
Ethanol
Alcohols
Control Groups

Keywords

  • Alcohol-related liver disease
  • Glycyrrhizin
  • Liposome
  • Nanotechnology
  • Redox homeostasis
  • Transmethylation capacity

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Hepatoprotective liposomal glycyrrhizin in alcoholic liver injury. / Kleiner, Dénes; Hegyi, Gabriella; Urbanics, Rudolf; Dézsi, László; Robotka, Hermina; Fehér, E.; Sárdi, Éva; Szebeni, János; Blázovics, Anna.

In: European Journal of Integrative Medicine, Vol. 8, 01.09.2016, p. 23-28.

Research output: Contribution to journalArticle

Kleiner, D, Hegyi, G, Urbanics, R, Dézsi, L, Robotka, H, Fehér, E, Sárdi, É, Szebeni, J & Blázovics, A 2016, 'Hepatoprotective liposomal glycyrrhizin in alcoholic liver injury', European Journal of Integrative Medicine, vol. 8, pp. 23-28. https://doi.org/10.1016/j.eujim.2016.11.005
Kleiner, Dénes ; Hegyi, Gabriella ; Urbanics, Rudolf ; Dézsi, László ; Robotka, Hermina ; Fehér, E. ; Sárdi, Éva ; Szebeni, János ; Blázovics, Anna. / Hepatoprotective liposomal glycyrrhizin in alcoholic liver injury. In: European Journal of Integrative Medicine. 2016 ; Vol. 8. pp. 23-28.
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abstract = "Introduction Licorice root (Glycyrrhiza glabra L.) extract and its main active component glycyrrhizin, as well as derivates are well known hepatoprotective and gastroprotective agents. Liposomal applications of these compounds may prevent low bioavailability and side-effects, e.g. pseudoaldosteronism and has further benefits, because the nanoparticles with glycyrrhizin and glycyrrhetinic acid have enhanced uptake into the liver. Our aim was to study the hepatoprotective effect of liposomal glycyrrhizin treatment during long-term alcohol consumption in rats. Methods Harlan-Wistar (175–200 g) rats were randomly allocated into three groups: control, alcoholic, ethanol and liposomal glycyrrhizin-treated. The redox status of the liver was studied with the measurement of free sulfhydryl-group concentration and hydrogen-donor ability. Transmethylation capacity was measured in dimedone adduct form. Histological examination was carried out as well. Results Data showed mild elevation in the hydrogen-donor ability and slightly lowered free sulfhydryl level, although transmethylation capacity was significantly lowered (p < 0,05) in the alcoholic group. Liposomal glycyrrhizin caused no marked histological changes. Effect of the treatment on the redox homeostasis and transmethylation capacity was beneficial. Conclusions Liposomal glycyrrhizin treatment moderated the alcohol-related negative changes, therefore glycyrrhizin and/or its derivatives may have further impact in the treatment of alcoholic liver diseases.",
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AU - Dézsi, László

AU - Robotka, Hermina

AU - Fehér, E.

AU - Sárdi, Éva

AU - Szebeni, János

AU - Blázovics, Anna

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N2 - Introduction Licorice root (Glycyrrhiza glabra L.) extract and its main active component glycyrrhizin, as well as derivates are well known hepatoprotective and gastroprotective agents. Liposomal applications of these compounds may prevent low bioavailability and side-effects, e.g. pseudoaldosteronism and has further benefits, because the nanoparticles with glycyrrhizin and glycyrrhetinic acid have enhanced uptake into the liver. Our aim was to study the hepatoprotective effect of liposomal glycyrrhizin treatment during long-term alcohol consumption in rats. Methods Harlan-Wistar (175–200 g) rats were randomly allocated into three groups: control, alcoholic, ethanol and liposomal glycyrrhizin-treated. The redox status of the liver was studied with the measurement of free sulfhydryl-group concentration and hydrogen-donor ability. Transmethylation capacity was measured in dimedone adduct form. Histological examination was carried out as well. Results Data showed mild elevation in the hydrogen-donor ability and slightly lowered free sulfhydryl level, although transmethylation capacity was significantly lowered (p < 0,05) in the alcoholic group. Liposomal glycyrrhizin caused no marked histological changes. Effect of the treatment on the redox homeostasis and transmethylation capacity was beneficial. Conclusions Liposomal glycyrrhizin treatment moderated the alcohol-related negative changes, therefore glycyrrhizin and/or its derivatives may have further impact in the treatment of alcoholic liver diseases.

AB - Introduction Licorice root (Glycyrrhiza glabra L.) extract and its main active component glycyrrhizin, as well as derivates are well known hepatoprotective and gastroprotective agents. Liposomal applications of these compounds may prevent low bioavailability and side-effects, e.g. pseudoaldosteronism and has further benefits, because the nanoparticles with glycyrrhizin and glycyrrhetinic acid have enhanced uptake into the liver. Our aim was to study the hepatoprotective effect of liposomal glycyrrhizin treatment during long-term alcohol consumption in rats. Methods Harlan-Wistar (175–200 g) rats were randomly allocated into three groups: control, alcoholic, ethanol and liposomal glycyrrhizin-treated. The redox status of the liver was studied with the measurement of free sulfhydryl-group concentration and hydrogen-donor ability. Transmethylation capacity was measured in dimedone adduct form. Histological examination was carried out as well. Results Data showed mild elevation in the hydrogen-donor ability and slightly lowered free sulfhydryl level, although transmethylation capacity was significantly lowered (p < 0,05) in the alcoholic group. Liposomal glycyrrhizin caused no marked histological changes. Effect of the treatment on the redox homeostasis and transmethylation capacity was beneficial. Conclusions Liposomal glycyrrhizin treatment moderated the alcohol-related negative changes, therefore glycyrrhizin and/or its derivatives may have further impact in the treatment of alcoholic liver diseases.

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