Hepatoprotective effects of prostacyclins on CCl4-induced liver injury in rats

A. Divald, E. Ujhelyi, A. Jeney, K. Lapis, L. Institoris

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Certain biochemical parameters of acute liver injury induced by carbon tetrachloride were investigated in rats treated with prostacyclin (PGI2) and two of its derivatives. Serum glutamate oxalacetate transaminase elevation and both triglyceride accumulation and reduction of glycogen content in liver were significantly suppressed by PGI2, 7-oxo-PGI2, and 20-methyl-13,14-didehydro-2,4-m-interphenylene-PGI2 48 hr after the injury. Prostacyclins partially restored some of the parameters of injury even in doses of 10 μg/kg ip. When the compounds were given 24 hr after CCl4 intoxication, much more pronounced protection was observed than in the case of treatments 1 hr before administration of the hepatotoxin. Thus, all tested prostacyclins exerted significant protective effects on acute liver damage which is obtained mainly in the second phase of the injury.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalExperimental and Molecular Pathology
Volume42
Issue number2
DOIs
Publication statusPublished - 1985

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Prostaglandins I
Epoprostenol
Liver
Rats
Wounds and Injuries
Carbon Tetrachloride
Transaminases
Glycogen
Glutamic Acid
Triglycerides
Derivatives
Serum

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Hepatoprotective effects of prostacyclins on CCl4-induced liver injury in rats. / Divald, A.; Ujhelyi, E.; Jeney, A.; Lapis, K.; Institoris, L.

In: Experimental and Molecular Pathology, Vol. 42, No. 2, 1985, p. 163-166.

Research output: Contribution to journalArticle

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