Hepatitisvírusok és hepatocarcinogenesis.

Translated title of the contribution: Hepatitis viruses and hepatocarcinogenesis

András Kiss, G. Lotz, Novák Pál Kaposi, Z. Schaff

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

INTRODUCTION: Hepatocellular carcinoma (HCC) is one of the most frequent malignancies worldwide. Hepatitis viruses, as the hepatitis virus B (HBV) and hepatitis virus C (HCV), among other environmental factors, are undoubtedly listed in the etiology of HCC. Studies indicate that in the near future viral hepatitis will be of increasing importance in the etiology of HCC. AIM: This review briefly discusses the known carcinogenic effects of HBV and HCV in the light of experimental and human studies. RESULTS: Data show that viral proteins may directly interfere with gene products responsible for cell proliferation and cell growth, therefore this direct effect may influence the basic mechanism of the cell cycle. Many other signal transduction cascades may be affected as well. Direct integration of HBV viral sequences into the host genome increases the genomic instability. The genomic imbalance allows the development and survival of malignant clones bearing defected genomic information. CONCLUSION: HBV and HCV infection induce indirect and direct mechanisms through cellular damage, increased regeneration and cell proliferation, therefore enhancing the development of HCC.

Original languageHungarian
Pages (from-to)83-86
Number of pages4
JournalOrvosi Hetilap
Volume143
Issue number2
Publication statusPublished - Jan 13 2002

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Hepatitis Viruses
Hepatocellular Carcinoma
Cell Proliferation
Virus Integration
Cercopithecine Herpesvirus 1
Genomic Instability
Viral Proteins
Hepatitis C
Hepatitis
Regeneration
Signal Transduction
Cell Cycle
Clone Cells
Genome
Growth
Infection
Genes
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hepatitisvírusok és hepatocarcinogenesis. / Kiss, András; Lotz, G.; Kaposi, Novák Pál; Schaff, Z.

In: Orvosi Hetilap, Vol. 143, No. 2, 13.01.2002, p. 83-86.

Research output: Contribution to journalArticle

Kiss, A, Lotz, G, Kaposi, NP & Schaff, Z 2002, 'Hepatitisvírusok és hepatocarcinogenesis.', Orvosi Hetilap, vol. 143, no. 2, pp. 83-86.
Kiss, András ; Lotz, G. ; Kaposi, Novák Pál ; Schaff, Z. / Hepatitisvírusok és hepatocarcinogenesis. In: Orvosi Hetilap. 2002 ; Vol. 143, No. 2. pp. 83-86.
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