Hepatitis E virus in Common voles (Microtus arvalis) from an urban environment, Hungary: Discovery of a Cricetidae-specific genotype of Orthohepevirus C

Kornélia Kurucz, Dávid Hederics, Dominika Bali, Gábor Kemenesi, Győző Horváth, F. Jakab

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hepatitis E virus is a major causative agent of acute hepatitis worldwide. Despite its zoonotic potential, there is limited information about the natural chain of hepevirus infection in wildlife, and the potential reservoir species. In this study, we performed a HEV survey by heminested RT-PCR on rodent samples from an urban environment (in the city of Pécs, Hungary) and investigated the prevalence of the virus among these native rodent species (Apodemus agrarius, Apodemus flavicollis, Apodemus sylvaticus, Microtus arvalis and Myodes glareolus). HEV was detected exclusively in Common voles (M. arvalis), in 10.2% of screened voles, and 3.2% of all investigated samples from all species. Based on the phylogenetic analysis, our strain showed the closest homology with European Orthohepevirus C strains detected previously in faecal samples of birds of prey and Red fox, supporting the possibility of the dietary origin of these strains. In addition, our samples showed close phylogenetic relation with a South American strain detected in Necromys lasiurus (Cricetidae), but separated clearly from other Muridae-associated strains, suggesting the presence of a Cricetidae-specific genotype in Europe and South-America. Based on these results, we hypothesize the reservoir role of M. arvalis rodents for the European Cricetidae-specific Orthohepevirus C genotype.

Original languageEnglish
JournalZoonoses and Public Health
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Hepatitis E virus
Microtus arvalis
Arvicolinae
Hungary
Genotype
Murinae
genotype
rodents
Hepevirus
Rodentia
Apodemus agrarius
Apodemus flavicollis
Apodemus sylvaticus
sampling
Muridae
Clethrionomys glareolus
phylogeny
Vulpes vulpes
hepatitis
birds of prey

Keywords

  • Apodemus
  • Microtus arvalis
  • small mammal
  • urban habitat
  • vole

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Hepatitis E virus in Common voles (Microtus arvalis) from an urban environment, Hungary : Discovery of a Cricetidae-specific genotype of Orthohepevirus C. / Kurucz, Kornélia; Hederics, Dávid; Bali, Dominika; Kemenesi, Gábor; Horváth, Győző; Jakab, F.

In: Zoonoses and Public Health, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Hepatitis E virus is a major causative agent of acute hepatitis worldwide. Despite its zoonotic potential, there is limited information about the natural chain of hepevirus infection in wildlife, and the potential reservoir species. In this study, we performed a HEV survey by heminested RT-PCR on rodent samples from an urban environment (in the city of P{\'e}cs, Hungary) and investigated the prevalence of the virus among these native rodent species (Apodemus agrarius, Apodemus flavicollis, Apodemus sylvaticus, Microtus arvalis and Myodes glareolus). HEV was detected exclusively in Common voles (M. arvalis), in 10.2{\%} of screened voles, and 3.2{\%} of all investigated samples from all species. Based on the phylogenetic analysis, our strain showed the closest homology with European Orthohepevirus C strains detected previously in faecal samples of birds of prey and Red fox, supporting the possibility of the dietary origin of these strains. In addition, our samples showed close phylogenetic relation with a South American strain detected in Necromys lasiurus (Cricetidae), but separated clearly from other Muridae-associated strains, suggesting the presence of a Cricetidae-specific genotype in Europe and South-America. Based on these results, we hypothesize the reservoir role of M. arvalis rodents for the European Cricetidae-specific Orthohepevirus C genotype.",
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