Hepatitis C virus infection - Pathobiology and implications for new therapeutic options

Gary L. Davis, Kris Krawczynski, Gyongyi Szabo

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Despite progress in therapeutic approaches for the elimination of hepatitis C, chronic hepatitis C virus infection remains an important cause of liver disease. Therapeutic intervention with the currently available interferon-based treatment regimens is quite successful, but treatment is difficult to tolerate and is contraindicated in many patients. A better understanding of the HCV biology, immunopathology, and liver disease will help to design better therapeutic strategies. The American Association for the Study of Liver Diseases sponsored a single-topic conference on hepatitis C virus infection on March 4 and 5, 2005, to enhance our current knowledge in the areas of basic and clinical research related to antiviral and immunomodulatory therapies in hepatitis C disease. The faculty consisted of 23 invited experts in the field of viral hepatitis. The program was divided into four sections including: (a) replicative mechanisms and models; (b) viral-host interactions; and (c) antiviral drug development and new strategies; and (d) back to the bedside-current issues. This report summarizes each of the presentations sections.

Original languageEnglish
Pages (from-to)857-875
Number of pages19
JournalDigestive Diseases and Sciences
Volume52
Issue number4
DOIs
Publication statusPublished - Apr 2007

Fingerprint

Virus Diseases
Hepacivirus
Hepatitis C
Antiviral Agents
Liver Diseases
Therapeutics
Immunomodulation
Chronic Hepatitis C
Interferons
Hepatitis
Research

Keywords

  • Antivirals
  • Hepatitis C
  • Therapy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hepatitis C virus infection - Pathobiology and implications for new therapeutic options. / Davis, Gary L.; Krawczynski, Kris; Szabo, Gyongyi.

In: Digestive Diseases and Sciences, Vol. 52, No. 4, 04.2007, p. 857-875.

Research output: Contribution to journalReview article

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