Hepatitis C infected hemodialysis and renal transplant patients with elevated α-glutathione S-transferase have increased risk for liver damage

E. Sárváry, Zs Gerlei, E. Dinya, E. Tóth, M. Varga, R. Chmel, M. Molnár, A. Remport, B. Nemes, L. Kóbori, D. Görög, J. Fazakas, I. Gaal, J. Járay, F. Perner, R. Langer

Research output: Contribution to journalArticle

Abstract

Patients on hemodialysis (HD) and renal transplant recipients (RT) have a high prevalence of HCV infection. The aim of our study was to determine the prevalence of HCV-RNA in the anti-HCV positive patients and to compare the biochemical parameters of PCR(+) and PCR(-) subgroups. Methods: The 525 sera were screened for anti-HCV. HCV-RNA was detected by polymerase chain reaction (PCR) and liver enzymes [SGOT, SGPT, GGT, α-glutathione S-transferase (GST)] were measured. Results: Active viraemia was found only in 187 of 289 (65%) seropositive HD patients in contrast to 53 of 53 (100%) of seropositive RT patients. Significantly increased (p

Original languageEnglish
Pages (from-to)70-76
Number of pages7
JournalInterventional Medicine and Applied Science
Volume2
Issue number2
DOIs
Publication statusPublished - Jun 1 2010

Fingerprint

Hepatitis C
Glutathione Transferase
Renal Dialysis
Transplants
Kidney
Liver
Polymerase Chain Reaction
RNA
Viremia
Aspartate Aminotransferases
Alanine Transaminase
Enzymes
Infection
Serum

Keywords

  • α-glutathione S-transferase
  • anti-HCV
  • HCV carriers
  • HCV infection
  • HCV-PCR
  • hepatocellular damage
  • patients on hemodialysis
  • renal transplant

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Hepatitis C infected hemodialysis and renal transplant patients with elevated α-glutathione S-transferase have increased risk for liver damage",
abstract = "Patients on hemodialysis (HD) and renal transplant recipients (RT) have a high prevalence of HCV infection. The aim of our study was to determine the prevalence of HCV-RNA in the anti-HCV positive patients and to compare the biochemical parameters of PCR(+) and PCR(-) subgroups. Methods: The 525 sera were screened for anti-HCV. HCV-RNA was detected by polymerase chain reaction (PCR) and liver enzymes [SGOT, SGPT, GGT, α-glutathione S-transferase (GST)] were measured. Results: Active viraemia was found only in 187 of 289 (65{\%}) seropositive HD patients in contrast to 53 of 53 (100{\%}) of seropositive RT patients. Significantly increased (p",
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T1 - Hepatitis C infected hemodialysis and renal transplant patients with elevated α-glutathione S-transferase have increased risk for liver damage

AU - Sárváry, E.

AU - Gerlei, Zs

AU - Dinya, E.

AU - Tóth, E.

AU - Varga, M.

AU - Chmel, R.

AU - Molnár, M.

AU - Remport, A.

AU - Nemes, B.

AU - Kóbori, L.

AU - Görög, D.

AU - Fazakas, J.

AU - Gaal, I.

AU - Járay, J.

AU - Perner, F.

AU - Langer, R.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Patients on hemodialysis (HD) and renal transplant recipients (RT) have a high prevalence of HCV infection. The aim of our study was to determine the prevalence of HCV-RNA in the anti-HCV positive patients and to compare the biochemical parameters of PCR(+) and PCR(-) subgroups. Methods: The 525 sera were screened for anti-HCV. HCV-RNA was detected by polymerase chain reaction (PCR) and liver enzymes [SGOT, SGPT, GGT, α-glutathione S-transferase (GST)] were measured. Results: Active viraemia was found only in 187 of 289 (65%) seropositive HD patients in contrast to 53 of 53 (100%) of seropositive RT patients. Significantly increased (p

AB - Patients on hemodialysis (HD) and renal transplant recipients (RT) have a high prevalence of HCV infection. The aim of our study was to determine the prevalence of HCV-RNA in the anti-HCV positive patients and to compare the biochemical parameters of PCR(+) and PCR(-) subgroups. Methods: The 525 sera were screened for anti-HCV. HCV-RNA was detected by polymerase chain reaction (PCR) and liver enzymes [SGOT, SGPT, GGT, α-glutathione S-transferase (GST)] were measured. Results: Active viraemia was found only in 187 of 289 (65%) seropositive HD patients in contrast to 53 of 53 (100%) of seropositive RT patients. Significantly increased (p

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KW - HCV carriers

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KW - renal transplant

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