Hepatitis C and Innate Immunity: Recent Advances

G. Szabó, Angela Dolganiuc

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Eradication of hepatitis C virus (HCV) infection requires a complex and coordinated interplay between innate and adaptive immune responses that, when it fails, leads to chronic infection. In this review, the innate immune mechanisms by which HCV is sensed and by which HCV undermines host defense are discussed. The critical role of dendritic cells in antigen presentation and T-cell activation in addition to type I interferon production and interference of HCV with innate immune cell functions are reviewed. Finally, current and emerging therapeutic approaches targeting innate immune pathways are evaluated.

Original languageEnglish
Pages (from-to)675-692
Number of pages18
JournalClinics in Liver Disease
Volume12
Issue number3
DOIs
Publication statusPublished - Aug 2008

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Hepatitis C
Innate Immunity
Hepacivirus
Interferon Type I
Antigen Presentation
Adaptive Immunity
Virus Diseases
Dendritic Cells
T-Lymphocytes
Infection
Therapeutics

ASJC Scopus subject areas

  • Hepatology

Cite this

Hepatitis C and Innate Immunity : Recent Advances. / Szabó, G.; Dolganiuc, Angela.

In: Clinics in Liver Disease, Vol. 12, No. 3, 08.2008, p. 675-692.

Research output: Contribution to journalReview article

Szabó, G. ; Dolganiuc, Angela. / Hepatitis C and Innate Immunity : Recent Advances. In: Clinics in Liver Disease. 2008 ; Vol. 12, No. 3. pp. 675-692.
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