Hepatitis C vírus infekció és immunglobulin nehéz lánc génátrendezódés.

Translated title of the contribution: Hepatitis C and immunoglobulin heavy-chain gene rearrangement

B. Gasztonyi, A. Pár, L. Kereskai, László Pajor, Katalin Kiss, J. Szeberényi, G. Mózsik

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus (HCV) has cytopathogenic effect not only on hepatocytes, however on salivary glands, monocytes of peripheral blood and lymphoid cells, may explain the systemic manifestations of the infection. HCV activates B and T-cells, modifies the immune response, causes lymphoproliferation, leading the development of B-cell non-Hodgkin's lymphoma (NHL). In the majority of B-cell NHLs immunoglobulin heavy chain (IgH) and light chain (IgL) genes are rearranged and expressed on cell surface in the early stage of the ontogenesis. The analyses of IgH rearrangement prove the clonality of lymphoproliferative disorders giving a powerful approach to the B-cell origin identification of cell proliferation. PATIENTS AND METHODS: IgH gene rearrangements were examined from the sera of 57 chronic HCV infected patients and 11 HCV-positive cryoglobulinemic patients as well. RESULTS: Cryoglobulinemia was detected in 20% of all chronic hepatitis C virus infected patients and IgH rearrangement was observed in 10.29% (7/68), 4/7 patients (57.14%) suffered from cryoglobulinemia. CONCLUSIONS: These results support the hypothesis that IgH gene rearrangement in HCV positive patients can indicate the lymphoproliferative disorder in the HCV infection released B-cell proliferation and lymphoma development.

Original languageHungarian
Pages (from-to)767-770
Number of pages4
JournalOrvosi Hetilap
Volume143
Issue number15
Publication statusPublished - Apr 14 2002

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Immunoglobulin Heavy Chain Genes
Gene Rearrangement
Hepatitis C
Hepacivirus
Immunoglobulin Heavy Chains
Cryoglobulinemia
Lymphoproliferative Disorders
B-Cell Lymphoma
Chronic Hepatitis C
B-Lymphocytes
Cell Proliferation
Virus Diseases
Salivary Glands
Non-Hodgkin's Lymphoma
Monocytes
Hepatocytes
Blood Cells
Lymphocytes
T-Lymphocytes
Light

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hepatitis C vírus infekció és immunglobulin nehéz lánc génátrendezódés. / Gasztonyi, B.; Pár, A.; Kereskai, L.; Pajor, László; Kiss, Katalin; Szeberényi, J.; Mózsik, G.

In: Orvosi Hetilap, Vol. 143, No. 15, 14.04.2002, p. 767-770.

Research output: Contribution to journalArticle

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abstract = "Hepatitis C virus (HCV) has cytopathogenic effect not only on hepatocytes, however on salivary glands, monocytes of peripheral blood and lymphoid cells, may explain the systemic manifestations of the infection. HCV activates B and T-cells, modifies the immune response, causes lymphoproliferation, leading the development of B-cell non-Hodgkin's lymphoma (NHL). In the majority of B-cell NHLs immunoglobulin heavy chain (IgH) and light chain (IgL) genes are rearranged and expressed on cell surface in the early stage of the ontogenesis. The analyses of IgH rearrangement prove the clonality of lymphoproliferative disorders giving a powerful approach to the B-cell origin identification of cell proliferation. PATIENTS AND METHODS: IgH gene rearrangements were examined from the sera of 57 chronic HCV infected patients and 11 HCV-positive cryoglobulinemic patients as well. RESULTS: Cryoglobulinemia was detected in 20{\%} of all chronic hepatitis C virus infected patients and IgH rearrangement was observed in 10.29{\%} (7/68), 4/7 patients (57.14{\%}) suffered from cryoglobulinemia. CONCLUSIONS: These results support the hypothesis that IgH gene rearrangement in HCV positive patients can indicate the lymphoproliferative disorder in the HCV infection released B-cell proliferation and lymphoma development.",
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AU - Pár, A.

AU - Kereskai, L.

AU - Pajor, László

AU - Kiss, Katalin

AU - Szeberényi, J.

AU - Mózsik, G.

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