Hepatitis B-vírus- (HBV-) infekció és hepatocarcinogenesis

Translated title of the contribution: Hepatitis B virus (HBV) infection and hepatocarcinogenesis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hepatitis B virus is one of the most important etiologic factors of hepatocellular carcinoma. The present review discusses the molecular mechanisms of virus-induced carcinogenesis, indirect and direct effects of the infection. The cell damage-evoked regeneration and proliferation, as well as the viral proteins that induce chromosomal, genetic and epigenetic changes, play a key role in the multistep process leading to malignant cell transformation. Integration of HBV DNA in to the host DNA, activation of oncogenes and inactivation of tumor suppressor genes are of basic significance. The hepatitis B virus related complications such as cirrhosis and hepatocellular carcinoma can be prevented by vaccination or eradication of the virus with antiviral therapy.

Original languageHungarian
Pages (from-to)1045-1053
Number of pages9
JournalOrvosi Hetilap
Volume151
Issue number26
DOIs
Publication statusPublished - Jun 1 2010

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Virus Diseases
Hepatitis B virus
Hepatocellular Carcinoma
Viruses
DNA
Viral Proteins
Tumor Suppressor Genes
Oncogenes
Epigenomics
Antiviral Agents
Regeneration
Carcinogenesis
Vaccination
Fibrosis
Infection
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hepatitis B-vírus- (HBV-) infekció és hepatocarcinogenesis. / Pár, A.

In: Orvosi Hetilap, Vol. 151, No. 26, 01.06.2010, p. 1045-1053.

Research output: Contribution to journalArticle

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