Hepatic regeneration induces transient acute phase reaction: Systemic elevation of acute phase reactants and soluble cytokine receptors

Andras Kristof Fulop, Eva Pocsik, Marta Brozik, Csaba Karabelyos, Arpad Kiss, Istvan Novak, Csaba Szalai, Otto Dobozy, Andras Falus

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The growth factors present during liver regeneration partially overlap with the regulators of the hepatic acute phase response. We analysed the acute phase reaction and changes in soluble cytokine receptors after partial hepatectomy, when tissue injury inducing acute phase reaction and major reduction of liver mass occur simultaneously. Three acute phase proteins and mRNAs were determined by ELISA and northern blot hybridisation in rats. Serum levels of IL-6 and three soluble cytokine receptors (sTNF-αR I and II, sIL-6R) were detected by ELIBA or dot-blot assay. Time-course profiles of fibrinogen, α2-macroglobulin and haptoglobin proteins and mRNA are presented. Elevation of IL-6, soluble TNF-α receptors and soluble IL-6 receptor levels were also detected. The time-course of changes in haptoglobin concentration and elevation of soluble cytokine receptors is described by this in vivo experimental system. The results show good correlation with (post)transcriptional activation of immediate and delayed early gene products. These data suggest the involvement of both acute phase proteins and soluble cytokine receptors in the regulation of liver regeneration.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalCell biology international
Volume25
Issue number7
DOIs
Publication statusPublished - Jan 1 2001

Keywords

  • Acute phase proteins
  • Fibrinogen
  • Haptoglobin
  • Liver regeneration
  • Rat
  • Time-factor
  • sIL-6R
  • sTNF-R
  • α- macroglobulin

ASJC Scopus subject areas

  • Cell Biology

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