Hepatic lesions in Syrian golden hamsters with pancreatic carcinoma induced by N-nitrosobis(2-oxopropyl)amine (BOP).

A. Zalatnai, A. V. Schally

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hepatic lesions in 25 male and 24 female Syrian golden hamsters with N-Nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic cancer have been studied. Although BOP produced pancreatic cancer in 100% of the animals, its hepatocarcinogenic potential proved to be very weak, only occasional preneoplastic foci, neoplastic nodules and hepatocellular carcinoma developed. However, a broad spectrum of mainly proliferative, non-neoplastic alterations were found in the liver. The major site of alterations was the portal space, especially the biliary ducts were affected: bile duct hyperplasia, oval cell proliferation and formation of biliary cysts were the most frequently encountered changes. In the large ducts of the female hamsters a goblet cell metaplasia occurred, but the male animals were devoid of this lesion. Our results demonstrate that although the BOP is considered as a selective pancreatotropic nitrosamine derivate, it may cause various proliferative changes in the biliary duct system of hamsters.

Original languageEnglish
Pages (from-to)119-130
Number of pages12
JournalActa Morphologica Hungarica
Volume38
Issue number2
Publication statusPublished - 1990

Fingerprint

nitrosobis(2-oxopropyl)amine
Mesocricetus
Pancreatic Neoplasms
Cricetinae
Nitrosamines
Goblet Cells
Liver
Metaplasia
Biliary Tract
Bile Ducts
Hyperplasia
Cysts
Hepatocellular Carcinoma
Cell Proliferation
Pancreatic Carcinoma

ASJC Scopus subject areas

  • Anatomy

Cite this

Hepatic lesions in Syrian golden hamsters with pancreatic carcinoma induced by N-nitrosobis(2-oxopropyl)amine (BOP). / Zalatnai, A.; Schally, A. V.

In: Acta Morphologica Hungarica, Vol. 38, No. 2, 1990, p. 119-130.

Research output: Contribution to journalArticle

@article{7ba1df99dc47455199ff05085db1eff8,
title = "Hepatic lesions in Syrian golden hamsters with pancreatic carcinoma induced by N-nitrosobis(2-oxopropyl)amine (BOP).",
abstract = "Hepatic lesions in 25 male and 24 female Syrian golden hamsters with N-Nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic cancer have been studied. Although BOP produced pancreatic cancer in 100{\%} of the animals, its hepatocarcinogenic potential proved to be very weak, only occasional preneoplastic foci, neoplastic nodules and hepatocellular carcinoma developed. However, a broad spectrum of mainly proliferative, non-neoplastic alterations were found in the liver. The major site of alterations was the portal space, especially the biliary ducts were affected: bile duct hyperplasia, oval cell proliferation and formation of biliary cysts were the most frequently encountered changes. In the large ducts of the female hamsters a goblet cell metaplasia occurred, but the male animals were devoid of this lesion. Our results demonstrate that although the BOP is considered as a selective pancreatotropic nitrosamine derivate, it may cause various proliferative changes in the biliary duct system of hamsters.",
author = "A. Zalatnai and Schally, {A. V.}",
year = "1990",
language = "English",
volume = "38",
pages = "119--130",
journal = "Acta Morphologica Hungarica",
issn = "0236-5391",
publisher = "Akademiai Kiado",
number = "2",

}

TY - JOUR

T1 - Hepatic lesions in Syrian golden hamsters with pancreatic carcinoma induced by N-nitrosobis(2-oxopropyl)amine (BOP).

AU - Zalatnai, A.

AU - Schally, A. V.

PY - 1990

Y1 - 1990

N2 - Hepatic lesions in 25 male and 24 female Syrian golden hamsters with N-Nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic cancer have been studied. Although BOP produced pancreatic cancer in 100% of the animals, its hepatocarcinogenic potential proved to be very weak, only occasional preneoplastic foci, neoplastic nodules and hepatocellular carcinoma developed. However, a broad spectrum of mainly proliferative, non-neoplastic alterations were found in the liver. The major site of alterations was the portal space, especially the biliary ducts were affected: bile duct hyperplasia, oval cell proliferation and formation of biliary cysts were the most frequently encountered changes. In the large ducts of the female hamsters a goblet cell metaplasia occurred, but the male animals were devoid of this lesion. Our results demonstrate that although the BOP is considered as a selective pancreatotropic nitrosamine derivate, it may cause various proliferative changes in the biliary duct system of hamsters.

AB - Hepatic lesions in 25 male and 24 female Syrian golden hamsters with N-Nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic cancer have been studied. Although BOP produced pancreatic cancer in 100% of the animals, its hepatocarcinogenic potential proved to be very weak, only occasional preneoplastic foci, neoplastic nodules and hepatocellular carcinoma developed. However, a broad spectrum of mainly proliferative, non-neoplastic alterations were found in the liver. The major site of alterations was the portal space, especially the biliary ducts were affected: bile duct hyperplasia, oval cell proliferation and formation of biliary cysts were the most frequently encountered changes. In the large ducts of the female hamsters a goblet cell metaplasia occurred, but the male animals were devoid of this lesion. Our results demonstrate that although the BOP is considered as a selective pancreatotropic nitrosamine derivate, it may cause various proliferative changes in the biliary duct system of hamsters.

UR - http://www.scopus.com/inward/record.url?scp=0025617570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025617570&partnerID=8YFLogxK

M3 - Article

C2 - 2099099

AN - SCOPUS:0025617570

VL - 38

SP - 119

EP - 130

JO - Acta Morphologica Hungarica

JF - Acta Morphologica Hungarica

SN - 0236-5391

IS - 2

ER -