Hepaticus encephalopathia és májátültetés.

Translated title of the contribution: [Hepatic encephalopathy and liver transplantation].

Imre Fehérvári, Balázs Nemes, Dénes Görög, Zsuzsa Gerlei, László Kóbori

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

About 6500-7000 people/year die in Hungary due to liver cirrhosis which is often complicated with hepatic encephalopathy (HE). While conventional interpretation is that hepatic encephalopathy is a consequence of high blood ammonia level, recent data indicate that the degree of encephalopathy is related to systemic inflammatory response during decompensation. In this review the authors overview and analyze the latest treatment modalities of hepatic encephalopathy based on most recent findings. They found that frequently used evidence based treatment which apply metronidazole, neomycine or disaccharides was only partially effective in clinical studies. Use of rifaximine only is supported by grade I evidence, however it is quite a costly drug. The authors could not identify a generally accepted guideline for the treatment of HE with a systematic literature review, although it has significant effect on survival after liver transplantation. Therefore, the authors urge to develop a consensus guideline for the treatment of HE.

Original languageHungarian
Pages (from-to)58-62
Number of pages5
JournalMagyar sebészet
Volume65
Issue number2
DOIs
Publication statusPublished - Apr 2012

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Hepatic Encephalopathy
Liver Transplantation
Guidelines
Hungary
Disaccharides
Metronidazole
Brain Diseases
Therapeutics
Ammonia
Liver Cirrhosis
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hepaticus encephalopathia és májátültetés. / Fehérvári, Imre; Nemes, Balázs; Görög, Dénes; Gerlei, Zsuzsa; Kóbori, László.

In: Magyar sebészet, Vol. 65, No. 2, 04.2012, p. 58-62.

Research output: Contribution to journalArticle

Fehérvári, Imre ; Nemes, Balázs ; Görög, Dénes ; Gerlei, Zsuzsa ; Kóbori, László. / Hepaticus encephalopathia és májátültetés. In: Magyar sebészet. 2012 ; Vol. 65, No. 2. pp. 58-62.
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