Hepatic and mesenteric metabolism of C terminal pentapeptide of gastrin in the rat. I. Biliary excretion of labelled glycine pentapeptide

V. Varro, L. Varga, L. Csernay

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

The C terminal glycine pentapeptide of the gastrin when injected intravenously or intraportally into rats appeared in two forms in the bile as verified by thin layer radiochromatography and bioassay. One of the substances proved to be the unchanged, biologically active pentapeptide having a Phe NH2 group at its end; the other, biologically inactive, represents the Phe COOH variant of the same molecule. The enzymatic hydrolysis is evoked by liver amidases during hepatic transit of the pentapeptide. Both elimination and enzymatic degradation of the active C terminal group of gastrin are considered to occur in the rat liver, but under in vivo circumstances the former process seems to be more important.

Original languageEnglish
Title of host publicationActa Hepato-Gastroenterologica
Pages500-505
Number of pages6
Volume20
Edition6
Publication statusPublished - 1973

Fingerprint

Pentagastrin
Glycine
Liver
Amidohydrolases
Gastrins
Bile
Biological Assay
Hydrolysis
Hepatobiliary Elimination

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hepatic and mesenteric metabolism of C terminal pentapeptide of gastrin in the rat. I. Biliary excretion of labelled glycine pentapeptide. / Varro, V.; Varga, L.; Csernay, L.

Acta Hepato-Gastroenterologica. Vol. 20 6. ed. 1973. p. 500-505.

Research output: Chapter in Book/Report/Conference proceedingChapter

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