Hepatic acute-phase reaction in histamine-deficient gene targeted mice

A. Donászi-Ivanov, P. Scharek, A. Falus, A. K. Fülöp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Histamine is a versatile mediator that, according to in vitro studies, affects the synthesis of inflammatory cytokines and acute-phase proteins. The histidine-decarboxylase knockout (HDC-/-) mouse is a model of in vivo investigation of the physiologic and metabolic integration of the acute-phase response. These mice do not synthesise histamine and feeding them with histamine-poor diet they are almost completely histamine-deficient. We compared the serum concentrations of representatives of acute-phase plasma proteins, as well as the levels IL-6 and IL-1α in wild type and HDC-/- mice during local (turpentine-induced) or systemic (LPS-induced) inflammation. The level of some acute-phase proteins significantly differed in wild-type and HDC-/- mice while others remained unaffected. The IL-6 levels are also differ in the wild-type and histamine-deficient animals, suggesting that the effect of histamine is attained through IL-6, although direct effect is not disclosed yet.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalInflammopharmacology
Volume12
Issue number1
DOIs
Publication statusPublished - 2004

Fingerprint

Acute-Phase Reaction
Histamine
Acute-Phase Proteins
Liver
Genes
Interleukin-6
Turpentine
Histidine Decarboxylase
Interleukin-1
Knockout Mice
Blood Proteins
Cytokines
Diet
Inflammation
Serum

Keywords

  • Cytokines
  • Gene knock-out
  • Hepatic acute-phase proteins
  • Histamine
  • Systemic acute-phase reaction

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

Hepatic acute-phase reaction in histamine-deficient gene targeted mice. / Donászi-Ivanov, A.; Scharek, P.; Falus, A.; Fülöp, A. K.

In: Inflammopharmacology, Vol. 12, No. 1, 2004, p. 47-55.

Research output: Contribution to journalArticle

Donászi-Ivanov, A. ; Scharek, P. ; Falus, A. ; Fülöp, A. K. / Hepatic acute-phase reaction in histamine-deficient gene targeted mice. In: Inflammopharmacology. 2004 ; Vol. 12, No. 1. pp. 47-55.
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