Hepatic acute-phase reaction in histamine-deficient gene targeted mice

A. Donászi-Ivanov, P. Scharek, A. Falus, A. K. Fülöp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Histamine is a versatile mediator that, according to in vitro studies, affects the synthesis of inflammatory cytokines and acute-phase proteins. The histidine-decarboxylase knockout (HDC-/-) mouse is a model of in vivo investigation of the physiologic and metabolic integration of the acute-phase response. These mice do not synthesise histamine and feeding them with histamine-poor diet they are almost completely histamine-deficient. We compared the serum concentrations of representatives of acute-phase plasma proteins, as well as the levels IL-6 and IL-1α in wild type and HDC-/- mice during local (turpentine-induced) or systemic (LPS-induced) inflammation. The level of some acute-phase proteins significantly differed in wild-type and HDC-/- mice while others remained unaffected. The IL-6 levels are also differ in the wild-type and histamine-deficient animals, suggesting that the effect of histamine is attained through IL-6, although direct effect is not disclosed yet.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalInflammoPharmacology
Volume12
Issue number1
DOIs
Publication statusPublished - May 5 2004

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Keywords

  • Cytokines
  • Gene knock-out
  • Hepatic acute-phase proteins
  • Histamine
  • Systemic acute-phase reaction

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Pharmacology (medical)

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