Hepatic actions of progestogenic steroids

A. Kulcsar, J. Kulcsar-Gergely, G. Weisz, M. Udvardy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of two oral progestogens, norethisterone and d-norgestrel, were studied on hepatic functions in CFY female rats. In healthy animals both progestogens inhibited cytochrome-P-450 dependent nonspecific mixed function monooxygenases. Serum bilirubin and cholylglycin RIA values were normal. Protein and glycogen content of the liver remained intact after norethisterone and d-norgestrel reduced glycogen. The pathologic values characteristic of chronic carbon tetrachloride damage improved to a highly significant degree when these progestogens were simultaneously administered. The progestogens inhibited mixed function monooxygenases. We may presume that in this way they inhibited the formation of the hepatotoxic trichloromethyl free radical and improves several liver functions.

Original languageEnglish
Pages (from-to)1301-1305
Number of pages5
JournalArzneimittel-Forschung
Volume34
Issue number10
Publication statusPublished - 1984

Fingerprint

Progestins
Steroids
Norgestrel
Norethindrone
Liver
Mixed Function Oxygenases
Liver Glycogen
Carbon Tetrachloride
Glycogen
Bilirubin
Cytochrome P-450 Enzyme System
Rats
Reference Values
Animals
Serum
Proteins

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Kulcsar, A., Kulcsar-Gergely, J., Weisz, G., & Udvardy, M. (1984). Hepatic actions of progestogenic steroids. Arzneimittel-Forschung, 34(10), 1301-1305.

Hepatic actions of progestogenic steroids. / Kulcsar, A.; Kulcsar-Gergely, J.; Weisz, G.; Udvardy, M.

In: Arzneimittel-Forschung, Vol. 34, No. 10, 1984, p. 1301-1305.

Research output: Contribution to journalArticle

Kulcsar, A, Kulcsar-Gergely, J, Weisz, G & Udvardy, M 1984, 'Hepatic actions of progestogenic steroids', Arzneimittel-Forschung, vol. 34, no. 10, pp. 1301-1305.
Kulcsar A, Kulcsar-Gergely J, Weisz G, Udvardy M. Hepatic actions of progestogenic steroids. Arzneimittel-Forschung. 1984;34(10):1301-1305.
Kulcsar, A. ; Kulcsar-Gergely, J. ; Weisz, G. ; Udvardy, M. / Hepatic actions of progestogenic steroids. In: Arzneimittel-Forschung. 1984 ; Vol. 34, No. 10. pp. 1301-1305.
@article{b447ccfbdada445ab0a38efbd3ba8722,
title = "Hepatic actions of progestogenic steroids",
abstract = "The effects of two oral progestogens, norethisterone and d-norgestrel, were studied on hepatic functions in CFY female rats. In healthy animals both progestogens inhibited cytochrome-P-450 dependent nonspecific mixed function monooxygenases. Serum bilirubin and cholylglycin RIA values were normal. Protein and glycogen content of the liver remained intact after norethisterone and d-norgestrel reduced glycogen. The pathologic values characteristic of chronic carbon tetrachloride damage improved to a highly significant degree when these progestogens were simultaneously administered. The progestogens inhibited mixed function monooxygenases. We may presume that in this way they inhibited the formation of the hepatotoxic trichloromethyl free radical and improves several liver functions.",
author = "A. Kulcsar and J. Kulcsar-Gergely and G. Weisz and M. Udvardy",
year = "1984",
language = "English",
volume = "34",
pages = "1301--1305",
journal = "Drug Research",
issn = "2194-9379",
publisher = "Thieme",
number = "10",

}

TY - JOUR

T1 - Hepatic actions of progestogenic steroids

AU - Kulcsar, A.

AU - Kulcsar-Gergely, J.

AU - Weisz, G.

AU - Udvardy, M.

PY - 1984

Y1 - 1984

N2 - The effects of two oral progestogens, norethisterone and d-norgestrel, were studied on hepatic functions in CFY female rats. In healthy animals both progestogens inhibited cytochrome-P-450 dependent nonspecific mixed function monooxygenases. Serum bilirubin and cholylglycin RIA values were normal. Protein and glycogen content of the liver remained intact after norethisterone and d-norgestrel reduced glycogen. The pathologic values characteristic of chronic carbon tetrachloride damage improved to a highly significant degree when these progestogens were simultaneously administered. The progestogens inhibited mixed function monooxygenases. We may presume that in this way they inhibited the formation of the hepatotoxic trichloromethyl free radical and improves several liver functions.

AB - The effects of two oral progestogens, norethisterone and d-norgestrel, were studied on hepatic functions in CFY female rats. In healthy animals both progestogens inhibited cytochrome-P-450 dependent nonspecific mixed function monooxygenases. Serum bilirubin and cholylglycin RIA values were normal. Protein and glycogen content of the liver remained intact after norethisterone and d-norgestrel reduced glycogen. The pathologic values characteristic of chronic carbon tetrachloride damage improved to a highly significant degree when these progestogens were simultaneously administered. The progestogens inhibited mixed function monooxygenases. We may presume that in this way they inhibited the formation of the hepatotoxic trichloromethyl free radical and improves several liver functions.

UR - http://www.scopus.com/inward/record.url?scp=0021229077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021229077&partnerID=8YFLogxK

M3 - Article

C2 - 6542791

AN - SCOPUS:0021229077

VL - 34

SP - 1301

EP - 1305

JO - Drug Research

JF - Drug Research

SN - 2194-9379

IS - 10

ER -